HX600
Based on 1 Customer Validation
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.4%
- CAS No.: 172705-89-4
- Formule: C29H30N2O2
- Masse moléculaire:438.56
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Differentiation Inducing Compound Library
HY-L038
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Reprogramming Compound Library
HY-L039
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Transcription Factor-Targeted Library
HY-L090
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Nuclear Receptor Compound Library
HY-L126
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Metabolic Enzyme Compound Library
HY-L146
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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RXR α 1.9 μM (Ki) |
RXR β 0.64 μM (Ki) |
RXR γ 1 μM (Ki) |
HX600 (100-1000 μM; 24 h) is not directly neuroprotective against glutamate exposure[1].
HX600 (1 μM; 24 h) inhibits the expression of inflammatory mediators in primary microglia and prevents inflammation induced neuronal death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary Cortical Neuron Cells
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Concentration:0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
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Incubation Time:24 h
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Result:Showd HX600 was not able to prevent the glutamate induced neuronal death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ischemic Mice[1]
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Dosage:60 mg/kg
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Administration:Oral Gavage (p.o.)
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Result:Revealed that mice treated with HX600 had smaller lesion with the size of 21%, and significantly reduction in Iba-1, phospho-p38 and TREM-2 at protein level.
Chemical Information
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CAS No. 172705-89-4
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Appearance Solid
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Masse moléculaire 438.56
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Formule C29H30N2O2
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Color Yellow to orange
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SMILES
O=C(O)C1=CC=C(C2=NC3=CC=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [Content Brief]
[2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HX600 Related Classifications
HY-120875 Related Classifications
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