IKE16
IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection.
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- Formule: C36H36N8O4
- Masse moléculaire:644.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
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Activité biologique
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Topoisomerase II 13.68 μM (IC50) |
Chemical Information
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Masse moléculaire 644.72
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Formule C36H36N8O4
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SMILES
O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN4CCN(CCCNC5=C(C([N+]([O-])=O)=CC=C6)C6=NC7=CC=CC=C75)CC4)=C21)[O-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IKE16 Related Classifications
HY-178330 Related Classifications
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