Cat. No.: HY-A0134

Isoflurane

23 Cited Publications

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Based on 23 publication(s) in Google Scholar

Isoflurane is a volatile anaesthetic. Isoflurane diminishs the effect of ROS activity. Isoflurane suppresses respiration. Isoflurane enables rapid anesthesia induction and emergence. Isoflurane protects against noise-induced hearing loss and tissue damage in mice. Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration.

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Pureté: 99.27%
CAS No.: 26675-46-7
Formule: C₃H₂ClF₅O
Masse moléculaire:184.49

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Isoflurane Chemical Structure

CAS No.: 26675-46-7

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Activité biologique
- Description
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (23)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

Isoflurane (0.04-2000 μM) specifically inhibits complex I-coupled respiration in permeabilized thoracic tissues of *Drosophila melanogaster*, with an IC₅₀ of approximately 356 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anesthesia with Isoflurane (1.2-1.5 vol%; inhalation; 3 h per day for 3 consecutive days) protects mice from noise-induced hearing loss and tissue damage, thereby reducing the severity of hearing threshold shifts and improving their reversibility, while increasing hair cell survival rate^[2].
Anesthesia with 1.2% Isoflurane (inhalation) significantly alleviates renal ischemia-reperfusion injury in mice by improving renal function, reducing necrosis, and regulating inflammation and leukocyte infiltration^[3].
Isoflurane (2.8%-5%; inhalation; 2-50 min) enables rapid anesthesia induction and emergence (1-2 min) in healthy female C57BL/6J mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (4 weeks of age, normal Preyer’s reflex, normal hearing threshold)^[2]
Dosage:

1.2 to 1.5 vol%
Administration:

inhaled; 3 hours per day; 3 consecutive days
Result:

Recorded a pre-exposure hearing threshold of 14.1 ± 4 dB HL, which increased to 44.1 ± 7 dB HL 1 day after noise exposure, 35.8 ± 4 dB HL 1 week after exposure, and 26.5 dB HL 1 month after exposure. Observed 90% survival rate of outer hair cells in the basal turn (80% of the total length from the apex), and 100% survival rate of inner hair cells in the basal turn.

Animal Model:

C57BL/6 (male, 25-30g, renal ischemia-reperfusion injury model)^[3]
Dosage:

1.2%
Administration:

inhaled
Result:

Measured plasma creatinine at 0.9 ± 0.1 mg/dL at 3 h and 1.3 ± 0.1 mg/dL at 24 h after ischemia, values significantly lower than pentobarbital group at both time points; Detected renal tubular necrosis grade at 0.8 ± 0.3 at 24 h after ischemia, significantly lower than pentobarbital group; Recorded renal cortical myeloperoxidase activity at 1.8 ± 0.4 OD/min per mg protein at 24 h after ischemia, significantly lower than pentobarbital group; Quantified neutrophil infiltration at 13.5 ± 7.3 neutrophils/mm² at 24 h after ischemia, significantly lower than pentobarbital group; Reduced ICAM-1 expression, macrophage infiltration, pro-inflammatory mRNA (TNF-α, IL-1β, KC, ICAM-1) upregulation, and NFκB nuclear translocation compared to pentobarbital group; Observed significantly less CD3+, CD8+, and NK1.1+ lymphocyte infiltration at 3 h after ischemia; Found CD4+ lymphocyte infiltration not statistically different between isoflurane and pentobarbital groups at 3 h after ischemia; Noted only NK1.1+ lymphocyte reduction persisted at 24 h after ischemia, with CD3+ and CD8+ lymphocyte counts not significantly different between isoflurane and pentobarbital groups at 24 h after ischemia

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 26675-46-7
Appearance Liquid (Density: 1.5 g/cm³)
Masse moléculaire 184.49
Formule C₃H₂ClF₅O
Color Colorless to light yellow
SMILES

FC(F)(F)C(Cl)OC(F)F
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (23)

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Cancer Commun (Lond)

HMGB3 promotes brain metastasis of lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism. [Abstract]

2025 Nov 5. PMID: 41194553
Chem Eng J

2025 Dec 16;527:171909.
Adv Healthc Mater

An Integrated Nanozyme-Exosome Platform for Multi-Targeted Therapy of Metabolic-Associated Steatotic Liver Disease. [Abstract]

2026 Jun;15(22):e71147. PMID: 41968605
Br J Pharmacol

Activated gasdermin E (GSDME) amplifies endoplasmic reticulum stress and inflammation in β-adrenoceptor overactivation-induced cardiac injury. [Abstract]

2026 Jun 2. PMID: 42226696
Neural Regen Res

The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth. [Abstract]

2026 Apr 1;21(4):1641-1651. PMID: 40587243
Phytother Res

IL-23 Receptor Agonism by Mulberroside C Activates the RASGRP1/RAS/ERK Pathway Contributing to Leukopenia Treatments. [Abstract]

2025 Aug;39(8):3578-3600. PMID: 40619172
Liver Int

Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis. [Abstract]

2026 Jun;46(6):e70696. PMID: 42130159
Inflammation

Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway. [Abstract]

2025 Jun 18. PMID: 40528120
Int Immunopharmacol

Ultrasound-activated piezoelectric BZT Nanocubes mediate direct Piezocatalytic killing and reverse immunosuppressive tumor microenvironment for effective hepatocellular carcinoma therapy. [Abstract]

2025 Dec 15:169:116035. PMID: 41401658
Discov Nano

Engineering L-Arg@ZIF-8 nanoparticles to modulate the immune-osteogenic-angiogenic microenvironment for accelerated bone fracture healing. [Abstract]

2026 May 2;21(1):157. PMID: 42068476
Cancer Sci

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway. [Abstract]

2026 Jul;117(7):1883-1893. PMID: 42023818
Biochim Biophys Acta Mol Basis Dis

Silencing RGS7 attenuates atrial fibrillation progression by activating the cGMP-PKG signaling pathway. [Abstract]

2025 Jun;1871(5):167786. PMID: 40086518
Lipids Health Dis

Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS. [Abstract]

2023 Jan 25;22(1):13. PMID: 36698123
Transl Oncol

Zeaxanthin targets TOP2A to regulate autophagy and suppress lung cancer progression via the MAPK/ERK pathway. [Abstract]

2026 Feb:64:102658. PMID: 41496415
Sci Rep

Wogonin attenuates psoriasis through anti-inflammatory effects by inhibiting reactive oxygen species production and the AKT/NF-κB signaling pathway. [Abstract]

2026 Apr 18;16(1):18101. PMID: 42000881
Sci Rep

Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway. [Abstract]

2026 Feb 13;16(1):8754. PMID: 41688661
Sci Rep

Lactate regulates the YTHDF2-FTH1 axis to promote cardiomyocyte ferroptosis and aggravate myocardial ischemia-reperfusion injury. [Abstract]

2026 Jan 8. PMID: 41507543
Sci Rep

HMMR mediates progression of nasopharyngeal carcinoma by inhibiting FAM83D ubiquitination and activating beta-catenin signaling pathway. [Abstract]

2025 Oct 13;15(1):35701. PMID: 41083782
Brain Res Bull

Dexmedetomidine ameliorates postoperative delirium-like behavior in aged mice by restoring microglial autophagy via MAPK14 inhibition. [Abstract]

2026 Apr:237:111839. PMID: 41865902
Animal Model Exp Med

Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma. [Abstract]

2025 Apr;8(4):696-706. PMID: 38225728
J Integr Neurosci

Resveratrol Alleviates Ischemia-Reperfusion-Induced Neuronal Damage by Inhibiting NR3C2-Mediated TRIM28 Expression. [Abstract]

2025 Mar 28;24(4):31375. PMID: 40302259
Neurosci Lett

Inhibition of the NF-κB/STAT3 pathway to reduce spinal microglia activation: a mechanism by which manual acupuncture alleviates rheumatoid arthritis. [Abstract]

2026 Apr 26:877:138560. PMID: 41763350
bioRxiv

2025 Jun 16.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (542.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.4203 mL

27.1017 mL

54.2035 mL

5 mM

1.0841 mL

5.4203 mL

10.8407 mL

10 mM

0.5420 mL

2.7102 mL

5.4203 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Rodriguez E, et al. Anaesthetics disrupt complex I-linked respiration and reverse the ATP synthase. Biochim Biophys Acta Bioenerg. 2025;1866(1):149511. [Content Brief]

[2]. Kim JU, et al. Protective effect of isoflurane anesthesia on noise-induced hearing loss in mice. Laryngoscope. 2005;115(11):1996-1999. [Content Brief]

[3]. Lee HT, et al. Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice. Am J Physiol Renal Physiol. 2007;293(3):F713-F722. [Content Brief]

[4]. Cesarovic N, et al. Isoflurane and sevoflurane provide equally effective anaesthesia in laboratory mice. Lab Anim. 2010;44(4):329-336. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.4203 mL	27.1017 mL	54.2035 mL	135.5087 mL
	5 mM	1.0841 mL	5.4203 mL	10.8407 mL	27.1017 mL
	10 mM	0.5420 mL	2.7102 mL	5.4203 mL	13.5509 mL
	15 mM	0.3614 mL	1.8068 mL	3.6136 mL	9.0339 mL
	20 mM	0.2710 mL	1.3551 mL	2.7102 mL	6.7754 mL
	25 mM	0.2168 mL	1.0841 mL	2.1681 mL	5.4203 mL
	30 mM	0.1807 mL	0.9034 mL	1.8068 mL	4.5170 mL
	40 mM	0.1355 mL	0.6775 mL	1.3551 mL	3.3877 mL
	50 mM	0.1084 mL	0.5420 mL	1.0841 mL	2.7102 mL
	60 mM	0.0903 mL	0.4517 mL	0.9034 mL	2.2585 mL
	80 mM	0.0678 mL	0.3388 mL	0.6775 mL	1.6939 mL
	100 mM	0.0542 mL	0.2710 mL	0.5420 mL	1.3551 mL

Keywords

Isoflurane

23 Cited Publications

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Isoflurane

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Publications Citing Use of MedChemExpress (MCE) Isoflurane

Activité biologique

Chemical Information

Publications (23)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Isoflurane

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

FDA-Approved Drug Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Anti-Cardiovascular Disease Compound Library

Endocrinology Compound Library

NMPA-Approved Drug Library

FDA Approved & Pharmacopeial Drug Library

Human Metabolite Library

Off-patent Drug Library

Mitochondrial Toxicity Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

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Bioactive Compound Library

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Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Isoflurane

Activité biologique

Chemical Information

Publications (23)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Isoflurane Related Classifications

HY-A0134 Related Classifications