JADA3
JADA3 is a molecular glue degrader targeting IKZF1 and IKZF3. JADA3 induces proteasome-mediated degradation of the target transcription factors by binding to the E3 ubiquitin ligase Cereblon. JADA3 can be used in research related to acute myeloid leukemia.
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- CAS No.: 2573901-15-0
- Formule: C10H10ClN3O2
- Masse moléculaire:239.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IKZF1 |
IKZF3 |
In Vitro
JADA3 (0.1-1 μM; 24 h) degrades IKZF1 and IKZF3 proteins in Jurkat cells[1].
JADA3 binds to CRBN in the CRBN fluorescence polarization (FP) displacement assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.1 and 1 μM
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Incubation Time:24 h
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Result:Induced CRBN-dependent ubiquitination and proteasomal degradation of IKZF1/IKZF3.
Chemical Information
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CAS No. 2573901-15-0
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Masse moléculaire 239.66
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Formule C10H10ClN3O2
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SMILES
O=CC=1C=NN2C(=O)C(=C(Cl)NC12)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JADA3 Related Classifications
HY-W450772 Related Classifications
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