KS 501
KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP)-sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia.
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- CAS No.: 120634-86-8
- Formule: C33H48O10
- Masse moléculaire:604.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
KS 501 (0-100 μM) inhibits calmodulin-sensitive phosphodiesterase activity in a concentration-dependent manner (IC50 = 0.8 μM)[1].
KS 501 (0.25-2 μM) shows a decreasing inhibitory effect on phosphodiesterase activity as the concentration of calmodulin increases[1].
KS 501 (10-40 μM) inhibits calmodulin-dependent synapsin I phosphorylation at 40 μM, while 10 μM has no inhibitory effect on basal activity and instead causes slight stimulation[1].
KS 501 (10-40 μM) inhibits the phosphorylation of synapsin I at site 1 (a substrate of calmodulin kinase I) and sites 2 and 3 (a substrate of calmodulin kinase II)[1].
KS 501 (10-40 μM) only partially inhibits synapsin I phosphorylation of cAMP-sensitive protein kinase (PKA)[1].
KS 501 (0-120 μM) inhibits the proliferation of L1210/S cells (IC50 = 80 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 120634-86-8
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Masse moléculaire 604.73
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Formule C33H48O10
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SMILES
CCCCCCCC1=CC(O)=CC(OC(C(C(CCCCCCC)=CC(O)=C2)=C2O[C@@H]3O[C@@]([C@@H]([C@H]3O)O)([H])[C@H](O)CO)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KS 501 Related Classifications
HY-117232 Related Classifications
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