LP-935001
LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.
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- CAS No.: 1875037-24-3
- Formule: C13H8ClFO2S
- Masse moléculaire:282.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
LP-935001 potently inhibits human Notum carboxylesterase activity in a cell-free biochemical assay with an IC50 of 0.4 nM[1].
LP-935001 restores Wnt/β-catenin signaling in a cell-based reporter assay in the presence of Notum with an EC50 of 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1875037-24-3
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Masse moléculaire 282.72
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Formule C13H8ClFO2S
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SMILES
O=C(C1=CC2=C(C3=C(CC2)C(Cl)=CC(F)=C3)S1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LP-935001 Related Classifications
HY-182632 Related Classifications
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