Melineurine
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC50 of 95.3 μM against AChE and an IC50 of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease.
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- CAS No.: 85802-28-4
- Formule: C17H17NO3
- Masse moléculaire:283.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Melineurine (100 μg/mL) inhibits electric eel acetylcholinesterase with an IC50 of 95.3 μM, with steric hindrance from its 3,3-dimethyl-2-propeneyloxyl substituent reducing its binding affinity compared to more potent acetylcholinesterase inhibitors[1].
Melineurine (0.1-1.0 μM, 100 μg/mL) inhibits horse serum butyrylcholinesterase with an IC50 of 28.0 μM via a mixed competitive mechanism, with strong binding affinity mediated by multiple hydrogen bonds and hydrophobic interactions with key active site residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 85802-28-4
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Masse moléculaire 283.32
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Formule C17H17NO3
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SMILES
COC1=C2C=COC2=NC3=C1C=CC(OC/C=C(C)/C)=C3
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melineurine Related Classifications
HY-N17394 Related Classifications
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