Methyclothiazide
Based on 1 Customer Validation
Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro.
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- Pureté: 99.28%
- CAS No.: 135-07-9
- Formule: C9H11Cl2N3O4S2
- Masse moléculaire:360.24
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-13513
U-104 -
HY-B1424
Benzthiazide -
HY-B2147
2-Aminobenzenesulfonamide -
HY-B0562R
Methyclothiazide (Standard) -
HY-B0553
Methazolamide -
HY-B0397
Dichlorphenamide -
HY-13650
Indisulam -
HY-B0122
Topiramate -
HY-101087
Benzenesulphonamide -
HY-B1471
Fluorometholone acetate -
HY-B0588
Brinzolamide -
HY-P99023
Girentuximab
Activité biologique
Description
IC50 & Target
IC50: voltage-dependent Ca-channel (VDCC)
In Vitro
Methyclothiazide (0-100 μM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from SHR, and the maximal vasoconstrictive effect of Norepinephrine (HY-13715) and arginine vasopressin (AVP) is decreased by 59% and 32.3 %, respectively[1]. Methyclothiazide (0-100 μM) induces inhibitory effect on the contractile response to Norepinephrine (HY-13715) is abolished by N-nitro-L-arginine (NOLA) but not indomethacin[1]. Methyclothiazide (100 μM) affects the vascular responses to extracellular Ca2+ under high-K+ depolarizing conditions. It can reduce Ca2+ contracture in a high-K+, Ca2+-free solution. The maximal contracture is reduced by 90.4%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 135-07-9
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Appearance Solid
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Masse moléculaire 360.24
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Formule C9H11Cl2N3O4S2
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Color White to off-white
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SMILES
O=S(C1=C(Cl)C=C(C2=C1)NC(CCl)N(C)S2(=O)=O)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
In Vitro:
DMSO : 72 mg/mL (199.87 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Colas, B., et al., Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol, 2000. 408(1): p. 63-7. [Content Brief]
[2]. Colas, B., et al., Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol, 2000. 14(4): p. 363-8. [Content Brief]
[3]. Sasaki, S. and R.D. Bunag, Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J Cardiovasc Pharmacol, 1983. 5(3): p. 378-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7759 mL | 13.8796 mL | 27.7593 mL | 69.3982 mL |
| 5 mM | 0.5552 mL | 2.7759 mL | 5.5519 mL | 13.8796 mL | |
| 10 mM | 0.2776 mL | 1.3880 mL | 2.7759 mL | 6.9398 mL | |
| 15 mM | 0.1851 mL | 0.9253 mL | 1.8506 mL | 4.6265 mL | |
| 20 mM | 0.1388 mL | 0.6940 mL | 1.3880 mL | 3.4699 mL | |
| 25 mM | 0.1110 mL | 0.5552 mL | 1.1104 mL | 2.7759 mL | |
| 30 mM | 0.0925 mL | 0.4627 mL | 0.9253 mL | 2.3133 mL | |
| 40 mM | 0.0694 mL | 0.3470 mL | 0.6940 mL | 1.7350 mL | |
| 50 mM | 0.0555 mL | 0.2776 mL | 0.5552 mL | 1.3880 mL | |
| 60 mM | 0.0463 mL | 0.2313 mL | 0.4627 mL | 1.1566 mL | |
| 80 mM | 0.0347 mL | 0.1735 mL | 0.3470 mL | 0.8675 mL | |
| 100 mM | 0.0278 mL | 0.1388 mL | 0.2776 mL | 0.6940 mL |
Methyclothiazide Related Classifications
HY-B0562 Related Classifications
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