MSU-43557
Based on 1 Customer Validation
MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection.
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- Pureté: 99.74%
- CAS No.: 2919699-59-3
- Formule: C15H17Cl2N3O
- Masse moléculaire:326.22
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MSU-43557 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro, and exhibits time-dependent bactericidal activity at a concentration of 5× MIC; meanwhile, MSU-43557 potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains[1].
MSU-43557 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC50 of 8.66 μM; it also reduces bacterial viability within biofilms, with a corresponding EC50 of 0.16 μM[1].
MSU-43557 (0.18 nM-160 μM; 3 d) kills intracellular Mycobacterium abscessus ATCC 19977 in mouse bone marrow-derived macrophages with an EC50 of 0.39 μM, and exhibits low cytotoxicity toward mouse bone marrow-derived macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
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Concentration:80 μM-0.08 nM
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Incubation Time:3 d
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Result:Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 1.29 μM and a MIC of 3.69 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.13 to 0.19 μM), Mycobacterium abscessus (EC50 of 1.82 μM), and Mycobacterium smegma (EC50 of 2.54 μM).
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Cell Line:Murine bone marrow-derived macrophages (BMMΦ)
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Concentration:200 to 0.13 μM
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Incubation Time:3 d
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Result:Resulted in a CC50 of >80 μM, indicating low cytotoxicity relative to intracellular efficacy.
Chemical Information
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CAS No. 2919699-59-3
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Appearance Solid
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Masse moléculaire 326.22
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Formule C15H17Cl2N3O
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Color White to off-white
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SMILES
CC1(CCCCC1)C(NC2=NC3=CC(Cl)=C(Cl)C=C3N2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (306.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0654 mL | 15.3271 mL | 30.6542 mL | 76.6354 mL |
| 5 mM | 0.6131 mL | 3.0654 mL | 6.1308 mL | 15.3271 mL | |
| 10 mM | 0.3065 mL | 1.5327 mL | 3.0654 mL | 7.6635 mL | |
| 15 mM | 0.2044 mL | 1.0218 mL | 2.0436 mL | 5.1090 mL | |
| 20 mM | 0.1533 mL | 0.7664 mL | 1.5327 mL | 3.8318 mL | |
| 25 mM | 0.1226 mL | 0.6131 mL | 1.2262 mL | 3.0654 mL | |
| 30 mM | 0.1022 mL | 0.5109 mL | 1.0218 mL | 2.5545 mL | |
| 40 mM | 0.0766 mL | 0.3832 mL | 0.7664 mL | 1.9159 mL | |
| 50 mM | 0.0613 mL | 0.3065 mL | 0.6131 mL | 1.5327 mL | |
| 60 mM | 0.0511 mL | 0.2555 mL | 0.5109 mL | 1.2773 mL | |
| 80 mM | 0.0383 mL | 0.1916 mL | 0.3832 mL | 0.9579 mL | |
| 100 mM | 0.0307 mL | 0.1533 mL | 0.3065 mL | 0.7664 mL |
MSU-43557 Related Classifications
HY-181283 Related Classifications
Powered by Bioz
- MSU-43557
- 2919699-59-3
- MSU43557
- MSU 43557
- Bacterial
- Mycobacterium abscessus ATCC 19977
- mycolic acid transport
- Mycobacterium abscessus mmpL3 mutants
- biofilm-associated Mycobacterium abscessus
- MmpL3
- murine bone marrow-derived macrophages
- MAB_4508
- Mycobacterium abscessus
- intracellular Mycobacterium abscessus
- trehalose monomycolate synthesis
- Inhibitor
- inhibitor
- inhibit