Multi-kinase-IN-3
Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively.
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- CAS No.: 2091950-43-3
- Formule: C33H33N5O3
- Masse moléculaire:547.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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PDGFRβ 55 ± 2.6 nM (IC50) |
VEGFR-2 58.3 ± 5.9 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
30.42 μM
Compound: 8h
|
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 28190652] |
| HT-29 | IC50 |
3.12 μM
Compound: 8h
|
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
|
[PMID: 28190652] |
| SK-OV-3 | IC50 |
25.87 μM
Compound: 8h
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Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 72 hrs by MTT assay
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[PMID: 28190652] |
Chemical Information
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CAS No. 2091950-43-3
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Masse moléculaire 547.65
-
Formule C33H33N5O3
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SMILES
O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N4C=CC=C4CN5CCN(C)CC5)C=C3)/C6=CC=CC=C6)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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