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Cat. No.: HY-181034

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NNRT-IN-15

NNRT-IN-15 (Compound 16a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-15 shows an EC₅₀ of 3 nM for WT HIV-1 and inhibits seven mutant strains (L100I, K103N, Y181C, etc.) (EC₅₀ = 8.2-43.4 nM). NNRT-IN-15 has low cytotoxicity against MT-4 cells (CC₅₀ = 196.46 μM). NNRT-IN-15 also inhibit WTHIV-1RT and hERG with IC₅₀ values of 0.7599 μM and 27.455 μM. NNRT-IN-15 can be used for research of HIV-1 infection.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₄H₃₆N₈O₃S
Masse moléculaire:636.77

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NNRT-IN-15 Chemical Structure

Stock

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

HIV-1

Voir tous les produits spécifiques à Isoform HIV :

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	MRT_0-t	MRT_0-∞	V_z	CL	F
Rat^[1]	1 mg/kg	i.v.	4.24 h	0.08 h	800 ng/mL	352 ng·h/mL	385 ng·h/mL	1.03 h	2.23 h	16.46 L/kg	3815 mL/min/kg	/
Rat^[1]	10 mg/kg	p.o.	2.45 h	1.5 h	29 ng/mL	79 ng·h/mL	86 ng·h/mL	2.41 h	3.18 h	/	/	2.06 %

Chemical Information

Masse moléculaire 636.77
Formule C₃₄H₃₆N₈O₃S
SMILES

O=S(C1=CC=C(CN2CCC(NC(N=C3N(C4=C(C)C=C(C5=CC=C(C#N)C=C5)C=C4C)C6)=NC=C3NC6=O)CC2)C=C1)(NC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang YX, et al. Cyclization-Inspired Structural Optimization: Designing Potent Non-nucleoside Reverse Transcriptase Inhibitors with Enhanced Safety and Selectivity. J Med Chem. 2026 Jan 22;69(2):1199-1217. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Cat. No.:
Quantité:
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NNRT-IN-15

Voir tous les produits spécifiques à Isoform HIV