Norbaeocystin
Norbaeocystin is an intermediate/minor metabolite naturally present in the psilocybin biosynthetic pathway of hallucinogenic mushrooms (Psilocybe spp.). Norbaeocystin has weak or no affinity for the serotonin 2A (5-HT2A) receptor and does not induce receptor activation. Norbaeocystin is rapidly metabolized by monoamine oxidase, and thus does not participate in centrally mediated psychedelic effects. Norbaeocystin can be used for studies on biological pathways associated with hallucinogenic effects.
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- CAS No.: 21420-59-7
- Formule: C10H13N2O4P
- Masse moléculaire:256.19
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Long-Evans (male, adult, PND 90-120)[1]
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Dosage:0.13 mg/kg; 0.25 mg/kg; 1.26 mg/kg; 2.52 mg/kg (broth vehicle); 0.1 mg/kg; 0.2 mg/kg; 1.0 mg/kg; 2.0 mg/kg (distilled water vehicle)
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Administration:p.o.; single dose
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Result:Failed to increase the rate of head twitch responses at any dose tested in either vehicle.
Showed no significant effect across doses in broth vehicle.
Showed no significant effect across doses in water vehicle.
Had no significant effect on locomotor behavior (total distance travelled or rearing events).
Chemical Information
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CAS No. 21420-59-7
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Masse moléculaire 256.19
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Formule C10H13N2O4P
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SMILES
O=P(O)(OC1=CC=CC2=C1C(CCN)=CN2)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Adams AM, et al. Development of an -based norbaeocystin production platform and evaluation of behavioral effects in rats. Metabolic engineering communications. 2022 Jun;14:e00196. [Content Brief]
[2].
Sherwood AM, et al. Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. J Nat Prod. 2020 Feb 28;83(2):461-467.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Norbaeocystin Related Classifications
HY-168809 Related Classifications
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- Norbaeocystin
- 21420-59-7
- Drug Intermediate
- 5-HT Receptor
- monoamine oxidase
- tryptamine biosynthetic substrate
- male Long-Evans rats
- 4-hydroxyindole
- hallucinogenic effect-related biological pathways
- serotonin 2A (5-HT2A) receptor
- rats
- recombinant E. coli BL21 Star? (DE3) strain Nor1
- blood-brain barrier
- Inhibitor
- inhibitor
- inhibit