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Cat. No.: HY-155108

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OATD-02

Name: OATD-02
Brand: MedChemExpress
SKU: HY-155108
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC₅₀s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2146132-73-0
Formule: C₁₂H₂₅BN₂O₄
Masse moléculaire:272.15

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

OATD-02 Chemical Structure

CAS No.: 2146132-73-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Pureté et documentation
Références
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Activité biologique

Description

IC₅₀ & Target

20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), 28 nM (rARG1)

In Vitro

OATD-02 inhibits mouse ARG in BMDM cells with IC₅₀ values of 912.9 nM and human ARG2 in transfected CHO-K1 cells with IC₅₀ of 171.6 nM, and inhibits hARG1 in human primary hepatocytes at a much higher micromolar concentration (IC₅₀ = 13 μM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OATD-02 (10 mg/kg, oral gavage) generates a strong and a long pharmacodynamic effect in vivo, and has oral bioavailability of 13%, 30%, and 61% from mouse through rat to dog, respectively^[1].
OATD-02 (5 mg/kg, oral gavage) increases fourfold of the L-arginine concentration in plasma sustained even 1 week after end of a treatment^[1].
OATD-02 (twice per day at 50 mg/kg, oral gavage) inhibits the tumor growth in B16F10 orthotopic xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16F10 orthotopic xenograft tumor model^[1]
Dosage:

Twice per day at 50 mg/kg for 15days
Administration:

Oral gavage
Result:

Inhibited tumor growth (TGI 46%).

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS No. 2146132-73-0
Masse moléculaire 272.15
Formule C₁₂H₂₅BN₂O₄
SMILES

N[C@]1(C(O)=O)C[C@H](CCB(O)O)CC[C@H]1CN(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Adv Sci (Weinh)

Blockade of CCR5+ T Cell Accumulation in the Tumor Microenvironment Optimizes Anti-TGF-β/PD-L1 Bispecific Antibody. [Abstract]

2024 Nov;11(43):e2408598. PMID: 39303165

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Borek B, et al. Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. Mol Cancer Ther. 2023;22(7):807-817. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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OATD-02

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (1)
Pureté et documentation
Références

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OATD-02

Publications Citing Use of MedChemExpress (MCE) OATD-02