P-gp modulator-5
P-gp modulator-5 (compound 25) is a modulator of P-gp and can inhibit the proliferation of multidrug resistant (MDR) tumors. P-gp modulator-5 inhibits the activity of drug efflux pumps in MDR cells, leading to a large accumulation of ROS and altered cell cycle profiles.
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- Formule: C19H16N2O5
- Masse moléculaire:352.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.22 μM
Compound: 25
|
Inhibition of human A549 cells incubated for 48 hrs by SRB method
Inhibition of human A549 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| COLO 205 | GI50 |
0.16 μM
Compound: 25
|
Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human COLO 205 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| DLD-1 | GI50 |
0.61 μM
Compound: 25
|
Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human DLD-1 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| H322 | GI50 |
0.174 μM
Compound: 25
|
Inhibition of human H322 cells incubated for 48 hrs by SRB method
Inhibition of human H322 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| K562 | GI50 |
0.25 μM
Compound: 25
|
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| LOX IMVI | GI50 |
0.19 μM
Compound: 25
|
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| MCF7 | GI50 |
0.15 μM
Compound: 25
|
Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human MCF7 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| MRC5 | GI50 |
1.53 μM
Compound: 25
|
Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method
Cytotoxicity against human MRC5 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| NCI/ADR-RES | GI50 |
0.23 μM
Compound: 25
|
Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human NCI-ADR-RES cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| NCI-H460 | GI50 |
0.35 μM
Compound: 25
|
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| OVCAR-3 | GI50 |
0.048 μM
Compound: 25
|
Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human OVCAR-3 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| OVCAR-8 | GI50 |
0.24 μM
Compound: 25
|
Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human OVCAR-8 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
| UACC-62 | GI50 |
0.16 μM
Compound: 25
|
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method
Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB method
|
[PMID: 39093920] |
Chemical Information
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Masse moléculaire 352.34
-
Formule C19H16N2O5
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SMILES
O=C1C=C(C(C2=C(C(C)=[N+](C=C21)[O-])C(OC)=O)=O)NCC3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)