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Cat. No.: HY-W679796

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PBITC

(Synonyms: 4-Phenylbutyl isothiocyanate)

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375).

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CAS No.: 61499-10-3
Formule: C₁₁H₁₃NS
Masse moléculaire:191.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PBITC Chemical Structure

CAS No.: 61499-10-3

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	27 μM Compound: 1c, PBITC	Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay	[PMID: 19053750]
HT-1080	IC₅₀	15 μM Compound: 1c, PBITC	Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay	[PMID: 19053750]
MDA-MB-231	IC₅₀	27 μM Compound: 1c, PBITC	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay	[PMID: 19053750]
PC-3	IC₅₀	24 μM Compound: 1c, PBITC	Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay	[PMID: 19053750]
T98G	IC₅₀	35 μM Compound: 1c, PBITC	Cytotoxicity against human T98G cells after 72 hrs by MTS assay Cytotoxicity against human T98G cells after 72 hrs by MTS assay	[PMID: 19053750]
UACC-903	IC₅₀	16 μM Compound: 1c, PBITC	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay	[PMID: 19053750]

Chemical Information

CAS No. 61499-10-3
Masse moléculaire 191.29
Formule C₁₁H₁₃NS
SMILES

S=C=NCCCCC1=CC=CC=C1
Synonyms

4-Phenylbutyl isothiocyanate
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Melissa A. Gimbor, et al. Abstract LB-464: Phenylbutyl isoselenocyanate (ISC-4) and phenylbutyl isothiocyanate (PBITC) inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lung tumorigenesis in A/J mouse. Cancer Res (2011) 71 (8_Supplement): LB-464.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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