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Cat. No.: HY-129265

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Poloxin-2

Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.

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CAS No.: 321695-37-8
Formule: C₁₆H₁₅NO₃
Masse moléculaire:269.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Poloxin-2 Chemical Structure

CAS No.: 321695-37-8

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Polo-like Kinase (PLK) :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	15 μM Compound: Poloxin-2	Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis	[PMID: 27425654]
HeLa	IC₅₀	10.5 μM Compound: Poloxin-2	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37607438]

Chemical Information

CAS No. 321695-37-8
Masse moléculaire 269.30
Formule C₁₆H₁₅NO₃
SMILES

O=C(C(C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Optimized Plk1 PBD inhibitors based on Poloxin induce mitotic arrest and apoptosis in tumor cells

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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