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Cat. No.: HY-145454A

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Preclamol

Name: Preclamol
Brand: MedChemExpress
SKU: HY-145454A
Availability: PreOrder

(Synonyms: (-)-3-PPP)

Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses.

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CAS No.: 85966-89-8
Formule: C₁₄H₂₁NO
Masse moléculaire:219.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Preclamol Chemical Structure

CAS No.: 85966-89-8

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	163 nM Compound: (-)-3PPP	Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 26555041]
CHO	EC₅₀	376 nM Compound: (-)-3PPP	Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM) Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)	[PMID: 26555041]
CHO	EC₅₀	51.9 nM Compound: (-)-3PPP	Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 26555041]
CHO	EC₅₀	844 nM Compound: (-)-3PPP	Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM) Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)	[PMID: 26555041]

Chemical Information

CAS No. 85966-89-8
Masse moléculaire 219.32
Formule C₁₄H₂₁NO
SMILES

CCCN1C[C@H](C2=CC(O)=CC=C2)CCC1
Synonyms

(-)-3-PPP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Preclamol [Content Brief]

[2]. Arnt J, et al. Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers. Psychopharmacology (Berl). 1983;81(3):199-207. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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