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Cat. No.: HY-N10348A

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Progoitrin potassium

Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).

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CAS No.: 21087-77-4
Formule: C₁₁H₁₈KNO₁₀S₂
Masse moléculaire:427.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Progoitrin potassium Chemical Structure

CAS No.: 21087-77-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Potassium progoitrin (1.4 μmol/g; 5-60 min at 150-200 °C) shows the lowest thermal stability in pH 9.0 phosphate buffer and undergoes thermal degradation to produce volatile flavor compounds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Progoitrin (potassium) (20-1000 mg; p.o.; s.c.; i.p.; 1 to 23.5 hours before I¹³¹ injection) exhibits dose-dependent antithyroid activity in male Holtzman rats, with oral administration generally more potent than subcutaneous or intraperitoneal routes at equivalent doses, reducing thyroidal I¹³¹ uptake to as low as 31.8% of control values^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Holtzman rats (male, 100-120 gm)^[3]
Dosage:

20 mg; 200 mg; 300 mg; 625 mg; 1000 mg
Administration:

p.o.; s.c.; i.p.; 1 to 23.5 hours before I¹³¹ injection
Result:

Reduced thyroidal I¹³¹ uptake.

Chemical Information

CAS No. 21087-77-4
Masse moléculaire 427.49
Formule C₁₁H₁₈KNO₁₀S₂
SMILES

C=C[C@H](O)C/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
Structure Classification
- Ketones, Aldehydes, Acids
- Glucosinolates
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhang Y, et al. Characterization of Thermally Induced Flavor Compounds from the Glucosinolate Progoitrin in Different Matrices via GC-TOF-MS. Journal of agricultural and food chemistry. 2022 Feb 02;70(4):1232-1240.

[2]. Collett MG, et al. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins. 2020 Nov 02;12(11):695. [Content Brief]

[3]. GREER MA, et al. Antithyroid activity elicited by the ingestion of pure progoitrin, a naturally occurring thioglycoside of the turnip family. J Clin Invest. 1959 Sep;38(9):1465-74. [Content Brief]

[4]. Liu Z, et al. Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family. Plant molecular biology. 2012 May;79(1-2):179-89. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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