LISK
LISK is the clan-level branch of the TKL group whose name combines its three constituent subfamilies: LRRK, IRAK, and STKR. These kinases share a TKL-type catalytic domain decorated with tandem regulatory modules — leucine-rich repeats, death domains, ankyrin repeats, or extracellular ligand-binding segments — that place receptor-proximal sensing directly on the kinase itself. Functionally they span innate immunity (IRAKs), TGF-beta/SMAD signaling in development and homeostasis (STKRs), and vesicle and cytoskeleton control (LRRKs). LISK proteins are drug targets in inflammation, fibrosis, and Parkinson's disease. Recombinant LISK-family kinases serve signaling, interaction, and inhibitor-discovery studies.
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LISK Protéines Recombinantes (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
