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Cat. No.: HY-P2045

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RA-VII

RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma.

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CAS No.: 86229-97-2
Formule: C₄₁H₅₀N₆O₉
Masse moléculaire:770.87

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RA-VII Chemical Structure

CAS No.: 86229-97-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.0033 μg/mL Compound: 1, RA-VII	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 24268554]
HL-60	IC₅₀	0.0025 μg/mL Compound: 1, RA-VII	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 24268554]
KB	IC₅₀	0.0023 μg/mL Compound: 1 (RA-VII)	Cytotoxicity in human epidermoid carcinoma of the nasopharynx(KB) cells Cytotoxicity in human epidermoid carcinoma of the nasopharynx(KB) cells	10.1016/S0960-894X(01)80580-1
L1210	IC₅₀	0.002 μg/mL Compound: 1	In vitro cytotoxicity against L1210 (murine leukemia) cells. In vitro cytotoxicity against L1210 (murine leukemia) cells.	10.1016/S0960-894X(01)80815-5
P388	IC₅₀	0.0013 μg/mL Compound: 1 (RA-VII)	Cytotoxicity in murine lymphocytic leukemia (P388) cells Cytotoxicity in murine lymphocytic leukemia (P388) cells	10.1016/S0960-894X(01)80580-1
P388	IC₅₀	0.0015 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18993061]
P388	IC₅₀	0.0022 μM Compound: 1, RA-VII	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 21382716]
P388	IC₅₀	0.003 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18078747]
P388	IC₅₀	0.0043 μg/mL Compound: 1, RA-VII	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 22460024]

Chemical Information

CAS No. 86229-97-2
Masse moléculaire 770.87
Formule C₄₁H₅₀N₆O₉
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Itokawa H, et al. Isolation and antitumor activity of cyclic hexapeptides isolated from Rubiae radix. Chem Pharm Bull (Tokyo). 1984 Jan;32(1):284-90. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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