RB-005
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer.
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- CAS No.: 1425049-20-2
- Formule: C21H35NO
- Masse moléculaire:317.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
SphK1 3.6 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
3.6 μM
Compound: RB-005
|
Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP
Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP
|
[PMID: 24164513] |
| Sf9 | IC50 |
3.6 μM
Compound: RB-005
|
Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting
Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liquid scintillation counting
|
[PMID: 25643074] |
Chemical Information
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CAS No. 1425049-20-2
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Masse moléculaire 317.51
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Formule C21H35NO
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SMILES
CCCCCCCCC1=CC=C(CCN2CCC(O)CC2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)