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Cat. No.: HY-122130

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SCH 2047069

Name: SCH 2047069
Brand: MedChemExpress
SKU: HY-122130
Availability: PreOrder

(Synonyms: MK-8267)

SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (K_d: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC₅₀ value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma.

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CAS No.: 1146209-50-8
Formule: C₂₀H₁₇F₄N₃O₂S
Masse moléculaire:439.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SCH 2047069 Chemical Structure

CAS No.: 1146209-50-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Kinesin :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	EC₅₀	3 nM Compound: 29, MK-8267	Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay Inhibition of KSP in human HCT116 cells assessed as phos-histone H3 level by immunofluorescent assay	[PMID: 25868746]

Chemical Information

CAS No. 1146209-50-8
Masse moléculaire 439.43
Formule C₂₀H₁₇F₄N₃O₂S
SMILES

CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O
Synonyms

MK-8267
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Basso AD, et al. SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics. Mol Cancer Ther. 2010 Nov;9(11):2993-3002. [Content Brief]

[2]. Nyamaa B, et al. Kinesin spindle protein inhibition in translational research. Journal of Lipid and Atherosclerosis, 2014, 3(2): 63-78.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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