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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-17629R
CAS No.: 54863-37-5
Synonyms: OLT1177 (Standard)
Domaines de recherche:
Dapansutrile (Standard) is the analytical standard of Dapansutrile. This product is intended for research and analytical applications. Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases .
Cat. No.: HY-184316
CAS No.: 98644-22-5
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CM 57373 is an orally active anorectic agent. CM 57373 releases serotonin and inhibits serotonin reuptake in rat brain synaptosomes. CM 57373 reduces food intake, decreases body weight and alleviates experimentally induced hyperphagia. CM 57373 can be used in obesity research .
Cat. No.: HY-B1776AS
CAS No.: 1173019-26-5
Cat. No.: HY-N10404
CAS No.: 121769-82-2
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Cat. No.: HY-N3562
CAS No.: 75513-81-4
Category:
Plant Flavonoids Neurological Disease Flavonones Cedrus deodara (Roxburgh) G. Don Extract Pinaceae Extract Disease Research Fields
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Cat. No.: HY-N7272
CAS No.: 13020-19-4
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Monophenols Abrus precatorius Linn. Extract Flavones Metabolic Disease Phenols Disease Research Fields
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Cat. No.: HY-N9516AR
CAS No.: 57011-24-2
Domaines de recherche:
Taurodehydrocholic acid (sodium) (Standard) is the analytical standard of Taurodehydrocholic acid (sodium) (HY-N9516A). This product is intended for research and analytical applications. Taurodehydrocholic acid sodium is a biliary cholesterol secretion activator. Taurodehydrocholic acid sodium significantly increases the expression of Abcg5 and decreases the expression of abc8. Taurodehydrocholic acid sodium can be used in the study of cholesterol metabolism .
Cat. No.: HY-P0104
CAS No.: 1447824-23-8
Target:
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Cat. No.: HY-P3548
CAS No.: 61090-95-7
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Cat. No.: HY-P3841
CAS No.: 309247-50-5
Cat. No.: HY-P99336
CAS No.: 142864-19-5
Synonyms: BI-RR 0001; Anti-Human IL6 Recombinant Antibody
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Domaines de recherche:
Cat. No.: HY-W653912A
Cat. No.: HY-113058R
CAS No.: 14292-27-4
Target:
Reference Standards Endogenous Metabolite Fungal Bacterial Interleukin Related Reactive Oxygen Species (ROS) Hydroxycarboxylic Acid Receptor (HCAR)
Domaines de recherche:
3-Hydroxyoctanoic acid (Standard) is the analytical standard of 3-Hydroxyoctanoic acid (HY-113058). This product is intended for research and analytical applications. 3-Hydroxyoctanoic acid is a medium-chain β-hydroxy fatty acid that possesses antibacterial, antifungal, and quorum-sensing regulatory activities. 3-Hydroxyoctanoic acid is an endogenous agonist of the human HCAR3 receptor, decreases intracellular cAMP, reduces IL-1beta secretion, increases IL-10 secretion, and decreases ROS production in macrophages. 3-Hydroxyoctanoic acid inhibits quorum-sensing-regulated pyocyanin production in Pseudomonas aeruginosa PAO1 and inhibits the yeast-to-hypha transition in Candida albicans. 3-Hydroxyoctanoic acid is used in research related to metabolism, bacterial infections, and fungal infections .
Cat. No.: HY-117578
CAS No.: 131916-69-3
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KB 5666 is a benzoxazine derivative with lipid peroxidation inhibitory activity. KB 5666 showed protective effects against post-ischemic neuronal death. KB 5666 effectively protected CA1 neurons when injected 5 minutes before or immediately after ischemia. KB 5666 also showed a dose-dependent protective effect when injected within 1 hour after ischemia. KB 5666 effectively prevented the significant decrease in microtubule-associated protein 2 immunoreactivity within the dendritic field of CA1 pyramidal cells. KB 5666 prevented the decrease in [3H]PDBu binding activity in different layers of the CA1 region after ischemia. The application of KB 5666 showed the ability to improve the cellular and functional consequences of ischemia .
Cat. No.: HY-122888
CAS No.: 2070837-24-8
MPT0L145 is a PIK3C3/FGFR inhibitor, with a Kd value of 0.53 nM for PIK3C3. MPT0L145 decreases the phosphorylation of FGFR1, FGFR3 and their downstream proteins (FRS2, ERK and Akt). MPT0L145 induces G0/G1 cell cycle arrest and decreased protein levels of cyclin E. MPT0L145 promotes mitochondrial dysfunction, ROS production, and DNA damage. MPT0L145 is an autophagy inhibitor. MPT0L145 significantly sensitizes cancer cells to targeted or chemotherapeutic agents. MPT0L145 can be used for cancer research, such as bladder cancer and NSCLC .
Cat. No.: HY-146223A
Pureté: 98.00%
(3R,10R,14aS)-AZD4625 is the isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625 is an orally active, selective irreversible, covalent allosteric GTPase KRASG12C inhibitor with an IC50 of 3 nM. AZD4625 can inhibit the MAPK pathway (with decreased pCRAF, pMEK, and pERK) and the PI3K pathway (with decreased pAKT and pS6), and induce cell apoptosis. AZD4625 has no binding and inhibition of wild-type RAS or isoforms carrying non-KRASG12C mutations. AZD4625 can be used for the study of KRASG12C mutant non-small cell lung cancer .
Cat. No.: HY-W700715
CAS No.: 1215622-76-6
Target:
Isotope-Labeled Compounds Endogenous Metabolite Fungal Bacterial Interleukin Related Reactive Oxygen Species (ROS) Hydroxycarboxylic Acid Receptor (HCAR)
Domaines de recherche:
3-Hydroxyoctanoic acid-d12 is the deuterated-labeled 3-Hydroxyoctanoic acid (HY-113058). 3-Hydroxyoctanoic acid is a medium-chain β-hydroxy fatty acid that possesses antibacterial, antifungal, and quorum-sensing regulatory activities. 3-Hydroxyoctanoic acid is an endogenous agonist of the human HCAR3 receptor, decreases intracellular cAMP, reduces IL-1beta secretion, increases IL-10 secretion, and decreases ROS production in macrophages. 3-Hydroxyoctanoic acid inhibits quorum-sensing-regulated pyocyanin production in Pseudomonas aeruginosa PAO1 and inhibits the yeast-to-hypha transition in Candida albicans. 3-Hydroxyoctanoic acid is used in research related to metabolism, bacterial infections, and fungal infections .
Category:
Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
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Target:
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LY255582 is a pan-opioid antagonist and has high affinity for mu, delta, and kappa receptors (Ki: 0.4 nM, 5.2, 2.0 nM respectively). LY255582 can decrease food intake and body weight. LY255582 can be used for the research of obesity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
