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Selegiline

(Synonyms: Deprenyl; (-)-Selegiline; (-)-Deprenyl)
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.

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  • CAS No.: 14611-51-9
  • Formule: C13H17N
  • Masse moléculaire:187.28
  • Stockage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Selegiline Chemical Structure
    Selegiline Chemical Structure
  • Experimental Validation Results for Selegiline
  • Experimental Validation Results for Selegiline
  • Experimental Validation Results for Selegiline
  • Experimental Validation Results for Selegiline
  • Experimental Validation Results for Selegiline
CAS No.: 14611-51-9
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  • Selegiline Chemical Structure
    Selegiline Chemical Structure
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    Selegiline purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]

    Customer Validation
     Schematic of the experimental timeline for analyzing the effects of the MAO-B inhibitor Selegiline hydrochloride (10 mg/kg, ip, 7 days) on CFA-induced allodynia and NETs formation.

  • 1/16

    Selegiline purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]

    Customer Validation
     Representative blots and quantification of MPO and citH3 in the spinal cords of vehicle, Selegiline hydrochloride, selegiline + CI-amidine, and Selegiline hydrochloride (10 mg/kg, ip, 7 days) + PMA groups.

  • 1/16

    Selegiline purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]

    Customer Validation
     Double immunofluorescence staining for citH3 (red) and MPO (green) in the spinal cords. NETs visualized by colocalization of citH3 and MPO staining (merged images; n = 3, scale bars: 50 or 100 μm). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

  • 1/16

    Selegiline purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]

    Customer Validation
     ELISAs detecting IL-1β, IL-6, and TNF-α in the spinal cords (n = 5, IL-1β: F3, 16 = 35.98, P < 0.0001; IL-6: F3, 16 = 58.79, P < 0.0001; TNF-α: F3, 16 = 155.5, P < 0.0001). The expression levels in the vehicle group were set to 1 for quantification. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the vehicle group mice. #P < 0.05, compared with the Selegiline hydrochloride (10 mg/kg, ip, 7 days) group mice.

  • 1/16

    Selegiline purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 Sep 21;21(1):250. [Abstract]

    Customer Validation
     Representative blots and quantification of GPR35 in the spinal cords of vehicle, FMD, FMD +  Selegiline hydrochloride (10 mg/kg, ip, 7 days), and FMD + 5-HIAA + PMA groups (n = 5, F3, 16 = 23.56, P < 0.0001).

  • Selegiline