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Cat. No.: HY-190192

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SG5-081

SG5-081 is an IKZF3 Molecular glue degrader. SG5-081 mediates CRBN-dependent ubiquitination and proteasomal degradation of IKZF3. SG5-081 does not reduce CK1α levels. SG5-081 can be used for research on multiple myeloma.

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CAS No.: 2133815-88-8
Formule: C₁₂H₉N₃O₄
Masse moléculaire:259.22

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Please store the product under the recommended conditions in the Certificate of Analysis.

SG5-081 Chemical Structure

CAS No.: 2133815-88-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
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- In Vitro
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Description

IC₅₀ & Target

^[1]

IKZF3

CRBN

Voir tous les produits spécifiques à Isoform IKZF Family :

In Vitro

Anti-cancerOthers

Anti-cancer

SG5-081 (100 µM; 24 h) reduces IKZF3 levels by approximately 40% without affecting CK1α in OPM-2 cells^[1].

Others

SG5-081 (Compound 5a) binds WT MsCI4 with a K_i >40 µM in the FRET assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

OPM-2 cells
Concentration:

100 µM
Incubation Time:

24 h
Result:

Significantly reduced IKZF3 levels by almost 40%.
No effect was observed on CK1α levels.

Chemical Information

CAS No. 2133815-88-8
Masse moléculaire 259.22
Formule C₁₂H₉N₃O₄
SMILES

O=C1N(C(C2)C(NC2=O)=O)C(C3=C1C=CC=C3N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Heim C, et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. Journal of medicinal chemistry. 2019 Jul 25;62(14):6615-6629. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SG5-081

Voir tous les produits spécifiques à Isoform IKZF Family

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IC50 & Target

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