SIQ17
SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research
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- CAS No.: 2151881-74-0
- Formule: C32H27NO2S
- Masse moléculaire:489.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
SIQ17 (10 μM, 72 hours) has a stronger inhibits on cell viability of A431 cells compare to A549 cells[1].
SIQ17 (0-100 μM, 24 hours) has thecytotoxic effects, with IC50s of 32.98 μM and 19.17μM for A549 cells and A431 cells respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, A431
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Concentration:10 μM
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Incubation Time:72 hours
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Result:Had a stronger inhibits on cell viability of A431 cells compare to A549 cells
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Cell Line:A549, A431, Vero cell lines
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Concentration:0-100 μM
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Incubation Time:24 hours
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Result:Had thecytotoxic effects, with IC50s of 32.98μM and 19.17μM for A549 cells and A431 cells respectively.
Chemical Information
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CAS No. 2151881-74-0
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Masse moléculaire 489.63
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Formule C32H27NO2S
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SMILES
O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIQ17 Related Classifications
HY-149846 Related Classifications
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