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Cat. No.: HY-155784

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SPC-180002

SPC-180002 is a SIRT1/3 dual inhibitor, with IC₅₀ values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.

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CAS No.: 2170274-53-8
Formule: C₁₈H₂₃NO₄
Masse moléculaire:317.38

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SPC-180002 Chemical Structure

CAS No.: 2170274-53-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

SIRT1

1.13 ± 0.3 μM (IC₅₀)

SIRT3

5.41 ± 4.8 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Sirtuin :

In Vitro

SPC-180002 (0-5 μM, 24 h) inhibits cell cycle progression via p21 accumulation, which causes subsequent cellular senescence^[1].
SPC-180002 dose not induce apoptosis and autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPC-180002 (1-5mg/kg, twice a week, i.p.) inhibits the growth of various cancer cells and impedes tumor growth in MCF7 tumor xenograft^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Five weeks female athymic nude mice (BALB/c)^[1]
Dosage:

1 mg/kg or 5 mg/kg
Administration:

i.p., twice a week
Result:

Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.

Chemical Information

CAS No. 2170274-53-8
Masse moléculaire 317.38
Formule C₁₈H₂₃NO₄
SMILES

O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Quantité:
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SPC-180002

Nicotinamide

Nicotinamide (Standard)

Sirtinol

SirReal2

Cambinol

Thiomyristoyl

SirReal2 (Standard)

SIRT2/6-IN-1

Nicotinamide (GMP)

Sirtinol (Standard)

Cambinol (Standard)

Thiomyristoyl (Standard)

Voir tous les produits spécifiques à Isoform Sirtuin

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

SPC-180002

Nicotinamide

Nicotinamide (Standard)

Sirtinol

SirReal2

Cambinol

Thiomyristoyl

SirReal2 (Standard)

SIRT2/6-IN-1

Nicotinamide (GMP)

Sirtinol (Standard)

Cambinol (Standard)

Thiomyristoyl (Standard)

Voir tous les produits spécifiques à Isoform Sirtuin

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SPC-180002 Related Classifications

HY-155784 Related Classifications

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