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Cat. No.: HY-183927

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Spectramide

Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D₂ receptor ligand. Spectramide shows no strong interactions with dopamine D₁ receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with ¹¹C or ¹²³I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538).

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CAS No.: 125141-02-8
Formule: C₁₉H₂₃ClIN₃O₂
Masse moléculaire:487.76

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Please store the product under the recommended conditions in the Certificate of Analysis.

Spectramide Chemical Structure

CAS No.: 125141-02-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Description

IC₅₀ & Target^[1]

D₂ Receptor

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In Vitro

¹²⁵I-Spectramide (increasing concentrations; 30 minutes) binds to a single population of high-affinity dopamine D₂ receptors in rat striatal homogenates with a K_d of 25 pM and a Bmax of 20 pmol/g tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 125141-02-8
Masse moléculaire 487.76
Formule C₁₉H₂₃ClIN₃O₂
SMILES

O=C(C1=CC(Cl)=C(NC)C=C1OC)NCCN(CC2=CC=C(C=C2)I)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sánchez-Roa PM, et al. [125]I-spectramide: a novel benzamide displaying potent and selective effects at the D2 dopamine receptor. Life Sci. 1989;45(19):1821-1829. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
Chemical Information
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Spectramide

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