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Cat. No.: HY-153573

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SRG-II-19F

(Synonyms: dCym-JQ1)

SRG-II-19F (dCym-JQ1) is a BRDTBD1 PROTAC degrader. Its dCym moiety at one end binds to the N-terminal domain of ClpC1 (ClpC1NTD), while its JQ1 moiety at the other end binds to bromodomain 1 of BRDT (BRDTBD1). This molecule induces the degradation of BRDTBD1 by recruiting the BRDTBD1 substrate to the ClpC1P1P2 protease complex. SRG-II-19F serves as a research tool for studies related to mycobacterial protein degradation.
(Pink: BRDT BD1 ligand (HY-13030); Blue: ClpC1 ligand (HY-P6300); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₈₀H₁₀₉ClN₁₆O₁₄S
Masse moléculaire:1586.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SRG-II-19F Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Références
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Activité biologique

Description

SRG-II-19F (dCym-JQ1) is a BRDTBD1 PROTAC degrader. Its dCym moiety at one end binds to the N-terminal domain of ClpC1 (ClpC1NTD), while its JQ1 moiety at the other end binds to bromodomain 1 of BRDT (BRDTBD1). This molecule induces the degradation of BRDTBD1 by recruiting the BRDTBD1 substrate to the ClpC1P1P2 protease complex. SRG-II-19F serves as a research tool for studies related to mycobacterial protein degradation^[1]. (Pink: BRDT BD1 ligand (HY-13030); Blue: ClpC1 ligand (HY-P6300); Black: linker).

IC₅₀ & Target^[1]

BRDT BD1

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain :

In Vitro

dCym-JQ1 (SRG-II-19F) (10 μM; 0-30 min) induces ClpC1P1P2-mediated degradation of BRDT_BD1 substrate in vitro, and this degradation is strongly inhibited by equimolar amounts of Mycobacterium smegmatis ClpC2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 1586.34
Formule C₈₀H₁₀₉ClN₁₆O₁₄S
SMILES

O=C(NCCOCCOCCOCCOCCN1N=NC(CN2C=C(C[C@@H](C(N(C)[C@@H](C[C@@H](C)CO)C(N[C@@H](C)C(N[C@@H]([C@H](OC)C3=CC=CC=C3)C(N[C@@H](C(C)C)C(N(C)[C@@H](CC(C)C)C(N[C@H]4C(C)C)=O)=O)=O)=O)=O)=O)NC4=O)C5=C2C=CC=C5)=C1)C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6
Synonyms

dCym-JQ1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hoi DM, et al. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell. 2023 May 11;186(10):2176-2192.e22. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SRG-II-19F

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SRG-II-19F Related Classifications

HY-153573 Related Classifications