TN-101
TN-101 is an orally active NLRP3 inhibitor (IC50 = 29.8 nM). TN-101 can be used for the study of obesity.
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- Formule: C18H20FIN2O3
- Masse moléculaire:458.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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NLRP3 29.8 nM (IC50) |
TN-101 (2 h) can effectively inhibit the secretion of IL-1β (IC50 = 5.58 nM) by THP-1 cells, under Lipopolysaccharides (HY-D1056) (LPS)/Nigericin (HY-127019) stimulation[1].
TN-101 (0.3 nM-6 μM, 1 h) can dose-dependently inhibit the secretion of IL-1β (IC50 = 5.97 nM) and IL-18 (IC50 = 12.2 nM) in THP-1 cells induced by Palmitic acid (HY-N0830)-BSA complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
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Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
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Administration:P.o., twice daily for 15 days
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Result:Showed no effect on the weight of DIO and NC lean mice.
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Animal Model:Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
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Dosage:1 mg/kg
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Administration:P.o., twice daily for 28 days
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Result:Showed no effect on the weight of DIO and NC lean mice.
Chemical Information
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Masse moléculaire 458.27
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Formule C18H20FIN2O3
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SMILES
O[C@]1(C[C@H](C1)NC(CN2C[C@@]3(C4=C(C2=O)C=CC(I)=C4)C[C@H]3F)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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