TNIK-IN-9
TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models.
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- CAS No.: 3038178-73-0
- Formule: C24H21N7O3S
- Masse moléculaire:487.53
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Pharmacokinetic Analysis in C57BL/6J Mouse Model[1]
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | AUCinf (ng·h/mL) | T1/2 (h) | C0 (ng/mL) | CL (mL/min/kg) | Cmax (ng/mL) | Tmax(h) |
| i.v. | 10 | 3019 | 3021 | 0.741 | 5059 | 56.2 | / | / |
| i.p. | 10 | 2525 | 2551 | 2.27 | / | / | 1280 | 0.50 |