TP-050
TP-050, a chemical probe, is a potent, orally active and selective NMDAR agonist with an EC50 value of 0.51 μM and 9.6 μM for GluN2A and GluN2D, respecticely. TP-050 can cross the blood-brain barrier (BBB). TP-050 induces hippocampal long-term (LPT) potentiation enhancemen and enhances neuronal signal transmission.
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- CAS No.: 3085030-47-0
- Formule: C16H15ClF2N6O
- Masse moléculaire:380.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
EC50: 0.51 µM (GluN2A) and 9.6 µM (GluN2D)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1]
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Dosage:10 mg/kg
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Administration:Oral administration
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Result:Induced LTP enhancement 24 h after oral administration of 10 mg/kg.
Chemical Information
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CAS No. 3085030-47-0
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Masse moléculaire 380.78
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Formule C16H15ClF2N6O
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SMILES
CC1=CN(C(C2=CC(CN3N=C(C=C3Cl)C(F)F)=NN12)=O)[C@@H](CC#N)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TP-050 Related Classifications
HY-148250 Related Classifications
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