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Cat. No.: HY-146287

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Zn(BQTC)

Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer.

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CAS No.: 2785342-54-1
Formule: C₃₀H₃₉Cl₂N₅O₃Zn
Masse moléculaire:653.95

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Zn(BQTC) Chemical Structure

CAS No.: 2785342-54-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC₅₀: 10 nM in A549R cells^[1]

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In Vitro

Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC₅₀ of 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

A549R, A549 and HL-7702^[1]
Concentration:

0-100 μM
Incubation Time:

6 hours
Result:

Exhibited potent antiproliferative activity against A549R and A549 cells with IC₅₀s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC₅₀ over 100 μM.

Chemical Information

CAS No. 2785342-54-1
Masse moléculaire 653.95
Formule C₃₀H₃₉Cl₂N₅O₃Zn
SMILES

O=C([N]12[Zn+2]([NH]3CC2)([NH]4CC3)[NH](CC4)CC1)CCCCCCOC5=C(OC6=CC=CC=C76)C7=NC8=CC=CC=C58.[Cl-].[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang ZF, et al. Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Zn(BQTC)

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Zn(BQTC) Related Classifications

HY-146287 Related Classifications