210344-98-2
210344-98-2
Chemical Structure
Z-IETD-FMK
Synonym(s): Z-IE(OMe)TD(OMe)-FMK
- CAS. Nr.: 210344-98-2
- Formula:C30H43FN4O11
- Molecular Weight:654.68
IUPAC Name: methyl (5S,8S,11S,14S)-5-((S)-sec-butyl)-14-(2-fluoroacetyl)-11-((R)-1-hydroxyethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
InChIKey: PHLCQASLWHYEMX-DEKIMQJDSA-N
SMILES: COC(C[C@@H](C(CF)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(OC)=O)NC([C@H]([C@@H](C)CC)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O
Biological Activity: Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor[1]. Z-IETD-FMK is also a granzyme B inhibitor[5].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Z-IETD-FMK | 98.0% | Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor. | ||||||||||||||||||||
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Z-IETD-FMK (Standard) | ≥98% | Z-IETD-FMK (Standard) is the analytical standard of Z-IETD-FMK (HY-101297). This product is intended for research and analytical applications. Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor. Z-IETD-FMK is also a granzyme B inhibitor. | ||||||||||||||||||||
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References
- [1]. Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. [Content Brief]
- [5]. Yang J, et al. Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells.Infect Immun. 2018 Dec 19;87(1). pii: e00386-18. [Content Brief]
