213971-34-7
213971-34-7
Chemical Structure
FX-11
Synonym(s): LDHA Inhibitor FX11
- CAS No.: 213971-34-7
- Formula:C22H22O4
- Molecular Weight:350.41
IUPAC Name: 7-benzyl-2,3-dihydroxy-6-methyl-4-propyl-1-naphthoic acid
InChIKey: LVPYVYFMCKYFCZ-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O
Biological Activity: FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FX-11 | 99.26% | FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts. | ||||||||||||||||||||
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FX-11 (Standard) | ≥98% | FX-11 (Standard) is the analytical standard of FX-11 (HY-16214). This product is intended for research and analytical applications. FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts. | ||||||||||||||||||||
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Sm4 | 99.01% | Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding (IC50 = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction (IC50 = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ, DDX1, DDX17, ILF3, SOX7 and STAT1, modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer. | ||||||||||||||||||||
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UBP646 | UBP646 is a potent GluN1/GluN2D receptors potentiator, and also potentiates the other three subtypes, GluN1/GluN2A, GluN1/GluN2B, and GluN1/GluN2C receptors. | |||||||||||||||||||||
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Amorfrutin A | Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis. | |||||||||||||||||||||
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Dihydropashanone | Dihydropashanone is a Chalcones product that can be isolated from the roots of Angelica pubescens. | |||||||||||||||||||||
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DMBP | 99.78% | DMBP is a VPS41 inhibitor. DMBP induces methuosis and inhibits autophagy in cancer cells. DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes. DMBP effectively inhibits metastasis in a mouse metastatic melanoma model. DMBP can be used for the study of melanoma. | ||||||||||||||||||||
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Isoarundinin II | 94.41% | Isoarundinin II is a bibenzyl compound found in the pseudobulbs of Pleione grandiflora (Rolfe) Rolfe. Isoarundinin II scavenges DPPH free radicals. | ||||||||||||||||||||
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2',6'-Dihydroxy-4'-methoxydihydrochalcone | 2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro. | |||||||||||||||||||||
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Pamoic acid (Standard) | ≥98% | Pamoic acid (Standard) is the analytical standard of Pamoic acid. This product is intended for research and analytical applications. Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties. | ||||||||||||||||||||
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Anthracene-9,10-dicarboxylic acid | 99.55% | Anthracene-9,10-dicarboxylic acid (9,10-Anthracenedicarboxylic acid) is a metal-organic framework (MOF). | ||||||||||||||||||||
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Tetracene-5,12-dicarboxylic acid | Tetracene-5,12-dicarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. EC Calvaresi. Small molecule inhibitors of lactate dehydrogenase a as an anticancer strategy. 2014.
- [2]. Le A, et, al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. [Content Brief]
- [3]. Mohammad GH, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel). 2019 Sep 16;11(9):1372. [Content Brief]
