220036-08-8
220036-08-8
Chemical Structure
NU6027
- CAS No.: 220036-08-8
- Formula:C11H17N5O2
- Molecular Weight:251.28
IUPAC Name: 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
InChIKey: DGWXOLHKVGDQLN-UHFFFAOYSA-N
SMILES: NC1=NC(OCC2CCCCC2)=C(N=O)C(N)=N1
Biological Activity: NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 μM and 1.3 μM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner[1][2].
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NU6027 | 98.01% | NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 μM and 1.3 μM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. | ||||||||||||||||||||
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References
- [1]. Arris CE, et, al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem. 2000 Jul 27; 43(15): 2797-804. [Content Brief]
- [2]. Peasland A, et, al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer. 2011 Jul 26;105(3):372-81. [Content Brief]
Keywords
