1. Cell Cycle/DNA Damage
  2. CDK
  3. NU2058

NU2058 (Synonyms: O6-(Cyclohexylmethyl)guanine)

Cat. No.: HY-19316 Purity: 99.01%
Handling Instructions

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

For research use only. We do not sell to patients.

NU2058 Chemical Structure

NU2058 Chemical Structure

CAS No. : 161058-83-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

IC50 & Target[1]

CDK1

26 μM (IC50)

CDK2

17 μM (IC50)

CDK2

12 μM (Ki)

In Vitro

NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

Molecular Weight

247.30

Formula

C₁₂H₁₇N₅O

CAS No.

161058-83-9

SMILES

NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (129.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0437 mL 20.2184 mL 40.4367 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL
10 mM 0.4044 mL 2.0218 mL 4.0437 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NU2058O6-(Cyclohexylmethyl)guanineNU 2058NU-2058CDKCyclin dependent kinasecompetitiveguanine-basedATPanti-cancerInhibitorinhibitorinhibit

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NU2058
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