1. Cell Cycle/DNA Damage
  2. CDK
  3. NU2058

NU2058 (Synonyms: O6-(Cyclohexylmethyl)guanine)

Cat. No.: HY-19316 Purity: 99.01%
Handling Instructions

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

For research use only. We do not sell to patients.

NU2058 Chemical Structure

NU2058 Chemical Structure

CAS No. : 161058-83-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 62 In-stock
Estimated Time of Arrival: December 31
5 mg USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 256 In-stock
Estimated Time of Arrival: December 31
100 mg USD 400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

IC50 & Target[1]

CDK1

26 μM (IC50)

CDK2

17 μM (IC50)

CDK2

12 μM (Ki)

In Vitro

NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

247.30

Formula

C₁₂H₁₇N₅O

CAS No.

161058-83-9

SMILES

NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (129.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0437 mL 20.2184 mL 40.4367 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL
10 mM 0.4044 mL 2.0218 mL 4.0437 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NU2058O6-(Cyclohexylmethyl)guanineNU 2058NU-2058CDKCyclin dependent kinasecompetitiveguanine-basedATPanti-cancerInhibitorinhibitorinhibit

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NU2058
Cat. No.:
HY-19316
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