2292-16-2
2292-16-2
Chemical Structure
Neferine
Synonym(s): (-)-Neferine
- CAS No.: 2292-16-2
- Formula:C38H44N2O6
- Molecular Weight:624.77
IUPAC Name: 4-(((S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol
InChIKey: MIBATSHDJRIUJK-ZWXJPIIXSA-N
SMILES: OC1=CC=C(C[C@@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC5=C(C=C4OC)CCN(C)[C@@H]5CC6=CC=C(OC)C=C6
Biological Activity: Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.
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Neferine | 99.92% | Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation. | ||||||||||||||||||||
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Neferine (Standard) | ≥98% | Neferine (Standard) is the analytical standard of Neferine. This product is intended for research and analytical applications. Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation. | ||||||||||||||||||||
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Dauricine (Standard) | ≥98% | Dauricine (Standard) is the analytical standard of Dauricine. This product is intended for research and analytical applications. Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose-and time-dependent manner in colon cancer. | ||||||||||||||||||||
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Daurisoline | 99.90% | Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer. | ||||||||||||||||||||
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Liensinine (Standard) | ≥98% | Liensinine (Standard) is the analytical standard of Liensinine (HY-N0484). This product is intended for research and analytical applications. Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke. | ||||||||||||||||||||
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Liensinine Diperchlorate | 99.96% | Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc. | ||||||||||||||||||||
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Isoliensinine (Standard) | ≥98% | Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells. | ||||||||||||||||||||
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N-Desmethyldauricine | N-Desmethyldauricine is a NF-κB p65 inhibitor and apoptosis inducer. N-Desmethyldauricine reduces the protein expression level of p65, induces apoptosis, arrests the cell cycle at the G0/G1 phase, attenuates intercellular adhesion, and inhibits the growth of 3D spheroids of triple-negative breast cancer. N-Desmethyldauricine can be used in studies related to triple-negative breast cancer. | |||||||||||||||||||||
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Dauricinoline | Dauricinoline is an orally active NF-κB inhibitor that can significantly inhibit NF-κB activation induced by TNF-α. Dauricinoline exhibits certain anti-inflammatory activity and can be used in the research of inflammatory diseases such as lung inflammation. | |||||||||||||||||||||
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Daurinoline | Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research. | |||||||||||||||||||||
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O-Methyldauricine | 96.1% | O-Methyldauricine ((-)-O-Methyldauricine) is an alkaloid with benzylisoquinoline group, which can be separated from P. ophthalmicus. O-Methyldauricine has antibacterial activity. | ||||||||||||||||||||
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Guattegaumerine | Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities. | |||||||||||||||||||||
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