2488892-01-7
2488892-01-7
Chemical Structure
TMX-2039
- CAS 番号: 2488892-01-7
- Formula:C17H20BrFN6O3S
- Molecular Weight:487.35
IUPAC Name: 2-((5-bromo-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide
InChIKey: WYMXMVOAIHZIFF-UHFFFAOYSA-N
SMILES: CS(=O)(N1CCC(CC1)NC2=NC=C(C(NC3=CC=CC(F)=C3C(N)=O)=N2)Br)=O
Biological Activity: TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5 and CDK6) and transcriptional CDKs (CDK7 and CDK9), with IC50s of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5 and 25 nM, respectively. TMX-2039 acts as a Ligands for Target Protein for PROTACs[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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TMX-2039 | 99.42% | TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5 and CDK6) and transcriptional CDKs (CDK7 and CDK9), with IC50s of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5 and 25 nM, respectively. TMX-2039 acts as a Ligands for Target Protein for PROTACs. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.64
HY-151071TMX-3013 -
Similarity Score 0.59
HY-10014RR547 (Standard) -
Similarity Score 0.56
HY-111260R547 mesylate -
Similarity Score 0.55
HY-103074GSK2226649A -
Similarity Score 0.55
HY-155593JNK-1-IN-2 -
Similarity Score 0.52
HY-170602JNK1 ligand-1-NH-Ph-COOH -
Similarity Score 0.52
HY-183071CDK7 ligand 3 -
Similarity Score 0.51
HY-163856CDK7-IN-30 -
Similarity Score 0.50
HY-173515FAK-IN-26 -
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