320-77-4
320-77-4
Chemical Structure
Isocitric acid
- CAS. Nr.: 320-77-4
- Formula:C6H8O7
- Molecular Weight:192.12
IUPAC Name: 1-hydroxypropane-1,2,3-tricarboxylic acid
InChIKey: ODBLHEXUDAPZAU-UHFFFAOYSA-N
SMILES: OC(C(O)=O)C(C(O)=O)CC(O)=O
Biological Activity: Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Isocitric acid | 99.14% | Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia. | ||||||||||||||||||||
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Isocitric acid (Standard) | 99.91% | Isocitric acid (Standard) is the analytical standard of Isocitric acid (HY-113228). This product is intended for research and analytical applications. Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia. | ||||||||||||||||||||
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rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate | 99.96% | rel-(2R,3S)-2,3-Dihydroxysuccinic acid (hydrate) is an endogenous metabolite. | ||||||||||||||||||||
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DL-4-Hydroxy-2-ketoglutarate | DL-4-Hydroxy-2-ketoglutarate is one of the metabolites that is characteristically elevated in the urine of patients with type 3 primary hyperoxaluria (PH3), and it is produced by the accumulation of substrates of mitochondrial 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate can be used in studies related to PH3. | |||||||||||||||||||||
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Hydroxycitric acid | 98.0% | Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation. | ||||||||||||||||||||
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2,3-Dihydroxysuccinic acid | 98.0% | 2,3-Dihydroxysuccinic acid (Tartaric acid) is an organic acid containing two hydroxyl groups and two carboxyl groups. 2,3-Dihydroxysuccinic acid exists in various stereoisomers and is widely used in food, pharmaceutical, chemical, and other fields. | ||||||||||||||||||||
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Tricarballylic acid (Standard) | 99.97% | Tricarballylic acid (Standard) is the analytical standard of Tricarballylic acid (HY-W020215). This product is intended for research and analytical applications. Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers. | ||||||||||||||||||||
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L-Tartaric acid ammonium | L-Tartaric acid (ammonium) (L-(+)-Tartaric acid (ammonium)) is a kind of biological materials or organic compounds that are widely used in life science research. | |||||||||||||||||||||
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(+)-Potassium Ds-threo-isocitrate monobasic | 99.95% | (+)-Potassium Ds-threo-isocitrate monobasic is a biologically active compound that has the activity of promoting cellular metabolism and regulating energy production. (+)-Potassium Ds-threo-isocitrate monobasic can also be used to study the regulation of metabolic pathways and enzyme activities. (+)-Potassium Ds-threo-isocitrate monobasic is widely used in biochemical research to explore its potential role in cellular function and disease processes. | ||||||||||||||||||||
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D-Tartaric acid | 99.79% | D-Tartaric acid (D-(-)-Tartaric acid) serves as an additive in beverages and other food products. When combined with pyrrole, D-Tartaric acid is used to construct a D-TA/polypyrrole-based bacterial imprinted polymer sensor for the detection of Vibrio parahaemolyticus. D-Tartaric acid enhances the sensitivity of polypyrrole-based bacterial imprinted polymer sensors for detecting Vibrio parahaemolyticus. D-Tartaric acid is applicable to research on Vibrio parahaemolyticus infection. | ||||||||||||||||||||
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DL-Tartaric acid | 98.0% | DL-Tartaric acid is an orally active and non-racemic mixture of L- and D-tartaric acid with antioxidant activity. 14C-labeled DL-Tartaric acid is nephrotoxic. | ||||||||||||||||||||
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References
- [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [Content Brief]
- [2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. [Content Brief]
- [3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. [Content Brief]
