3420-72-2
3420-72-2
Chemical Structure
Flavokawain A
- CAS No.: 3420-72-2
- Formula:C18H18O5
- Molecular Weight:314.33
IUPAC Name: (E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
InChIKey: CGIBCVBDFUTMPT-RMKNXTFCSA-N
SMILES: O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(OC)C=C2
Biological Activity: Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flavokawain A | 99.73% | Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer. | ||||||||||||||||||||
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Flavokawain A (Standard) | ≥98% | Flavokawain A is a chalcone compound and an orally active inhibitor of PRMT5 and cytochrome P450. Flavokawain A has anti-inflammatory, anti-tumor, and immunomodulatory effects. Flavokawain A can inhibit the proliferation of tumor cells and induce apoptosis. Flavokawain A can be used in the research of diseases such as bladder cancer. | ||||||||||||||||||||
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Nitric oxide production-IN-2 | Nitric oxide production-IN-2 (compound 39) is an inhibitor of nitric oxide (NO) production. Nitric oxide production-IN-2 inhibits LPS (HY-D1056)-induced nitric oxide production in RAW 264.7 cells, and it can be used in studies related to inflammation and nitric oxide production. | |||||||||||||||||||||
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4,2′,4′,6′-Tetramethoxychalcone | 99.51% | 4,2′,4′,6′-Tetramethoxychalcone is a flavonoids that can be isolated from Gnaphalium affine. | ||||||||||||||||||||
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3'-Methyl-4-O-methylhelichrysetin | 3'-Methyl-4-O-methylhelichrysetin is a Chalcones product that can be isolated from the barks of Cephalotaxus sinensis. | |||||||||||||||||||||
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4-O-Methylhelichrysetin | 99.95% | 4-O-Methylhelichrysetin is a Chalcones product that can be isolated from the herbs of Cephalotaxus sinensis. | ||||||||||||||||||||
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(E/Z)-Flavokawain B | (E/Z)-Flavokawain B (compound 4) is a chalcone and nitric oxide production inhibitor with an IC50 of 6.8 μM.(E/Z)-Flavokawain B can be found in the aerial parts of Sarcandra glabra.(E/Z)-Flavokawain B inhibits lipopolysaccharide-induced nitric oxide production. | |||||||||||||||||||||
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Flavokawain B (Standard) | ≥98% | Flavokawain B (Standard) is the analytical standard of Flavokawain B. This product is intended for research and analytical applications. Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations. | ||||||||||||||||||||
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Flavokawain C | 99.53% | Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway. Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer. | ||||||||||||||||||||
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(E)-Flavokawain A | 99.53% | (E)-Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E)-Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. | ||||||||||||||||||||
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Flavokawin C | 99.67% | Flavokawin C is a natural compound with antioxidative and cytotoxicity. | ||||||||||||||||||||
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2',6'-Dihydroxy-4,4'-dimethoxychalcone | 2',6'-Dihydroxy-4,4'-dimethoxychalcone is a Chalcones product that can be isolated from the herbs of Cephalotaxus sinensis. | |||||||||||||||||||||
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References
- [1]. Xiaolin Zi, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65(8):3479-86. [Content Brief]
- [2]. Jing S, et al. Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study. Front Bioeng Biotechnol. 2022 Dec 5;10:1071776. [Content Brief]
- [3]. Liu S, et al. Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer. J Exp Clin Cancer Res. 2022 Oct 5;41(1):293. [Content Brief]
- [4]. Abu N, et al. In vitro Toxicity and in vivo Immunomodulatory Effects of Flavokawain A and Flavokawain B in Balb/C Mice. Nat Prod Commun. 2015 Jul;10(7):1199-202. [Content Brief]
- [5]. Niu L, et al. Flavokawain A inhibits Cytochrome P450 in in vitro metabolic and inhibitory investigations. J Ethnopharmacol. 2016 Sep 15;191:350-359. [Content Brief]
