353-09-3
353-09-3
Chemical Structure
Ompenaclid
Synonym(s): RGX-202; 3-Guanidinopropionic acid
- CAS No.: 353-09-3
- Formula:C4H9N3O2
- Molecular Weight:131.14
IUPAC Name: 3-guanidinopropanoic acid
InChIKey: KMXXSJLYVJEBHI-UHFFFAOYSA-N
SMILES: O=C(O)CCNC(N)=N
Biological Activity: Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2].
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Ompenaclid | 99.94% | Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy. | ||||||||||||||||||||
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Ompenaclid (Standard) | ≥98% | Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy. | ||||||||||||||||||||
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References
- [1]. Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7(41):eabi7511. [Content Brief]
- [2]. Creisméas A, et, al. TRPC1 and TRPC3 involvement in DMD physiopathology and as potential targets for treatment in complement to rAAV-microdystrophin. 2021 Oct 1;13.
Keywords
