519-23-3
519-23-3
Chemical Structure
Ellipticine
Synonym(s): NSC 71795
- CAS No.: 519-23-3
- Formula:C17H14N2
- Molecular Weight:246.31
IUPAC Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
InChIKey: CTSPAMFJBXKSOY-UHFFFAOYSA-N
SMILES: CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4
Biological Activity: Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ellipticine | 99.59% | Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. | ||||||||||||||||||||
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Ellipticine (Standard) | ≥98% | Ellipticine (Standard) is the analytical standard of Ellipticine. This product is intended for research and analytical applications. Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. | ||||||||||||||||||||
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9-Hydroxyellipticin | 9-hydroxyellipticine is an inhibitor of Topo II and RyR, exhibiting high affinity for DNA with a Pka value of 9.8 at pH 7.4. It has antitumor, antioxidant, and catecholamine-releasing activities, with IC50 values of 1.6 μM and 1.2 μM for Hela S-3 and 293T cells, respectively. It also demonstrates anticancer effects in L1210 leukemia mice. | |||||||||||||||||||||
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9-Hydroxyellipticine hydrochloride | 99.9% | 9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively. | ||||||||||||||||||||
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CK-102 | CK-102 is an interleukin-1 (IL-1) inhibitor. CK-102 reduces mRNA synthesis. CK-102 does not inhibit DNA synthesis. CK-102 only slightly inhibits protein synthesis, or has no effect on it. CK-102 delays wound healing after ophthalmic surgery and prolongs the failure time of trabeculectomy fistulas. CK-102 inhibits lens protein-induced ocular inflammation at both early and late stages. CK-102 inhibits endotoxin-induced uveitis. CK-102 does not inhibit interleukin-1-induced uveitis. CK-102 can be used in research related to glaucoma filtration failure and uveitis. | |||||||||||||||||||||
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Ellipticine hydrochloride | 99.01% | Ellipticine (NSC 71795) hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. | ||||||||||||||||||||
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Elliptinium acetate | 99.01% | Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer. | ||||||||||||||||||||
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GQC-05 | GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex ( c-Myc G4) stabilizer with KD values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma. | |||||||||||||||||||||
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SMU-CX1 | 99.9% | SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5. | ||||||||||||||||||||
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Tetrahydroellipticine | Tetrahydroellipticine is an alkaloid that can be isolated from the seeds and root-bark of Pterotaberna inconspicua. | |||||||||||||||||||||
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γ-Carboline | 99.13% | γ-Carboline is a skeleton and antiviral agent. γ-Carboline shows anti-BVDV activity, with an EC50 of 2.0 μM. γ-Carboline derivatives show anti-BVDV, antibacterial, antifungal, antitumor activity. | ||||||||||||||||||||
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Norharmane | 99.93% | Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings. | ||||||||||||||||||||
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