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Cat. No.: HY-177872

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GQC-05

(Synonyms: NSC 338258)

GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex ( c-Myc G4) stabilizer with K_D values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma.

For research use only. We do not sell to patients.

CAS No.: 501662-77-7
Formula: C₂₁H₂₃N₃O
Molecular Weight:333.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

GQC-05 Chemical Structure

CAS No.: 501662-77-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CA46	IC₅₀	13 μM Compound: GQC-05; 14	Cytotoxicity against human CA46 cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human CA46 cells assessed as reduction in cell viability by MTS assay	[PMID: 33355454]
Raji	IC₅₀	2.6 μM Compound: GQC-05; 14	Cytotoxicity against human Raji cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human Raji cells assessed as reduction in cell viability by MTS assay	[PMID: 33355454]

Chemical Information

CAS No. 501662-77-7
Molecular Weight 333.43
Formula C₂₁H₂₃N₃O
SMILES

CN(C)CCOC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Synonyms

NSC 338258
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brown RV, et al. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286(47):41018-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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