623-91-6
623-91-6
Chemical Structure
(2E)-Diethyl fumarate
- CAS No.: 623-91-6
- Formula:C8H12O4
- Molecular Weight:172.18
IUPAC Name: diethyl fumarate
InChIKey: IEPRKVQEAMIZSS-AATRIKPKSA-N
SMILES: O=C(OCC)/C=C/C(OCC)=O
Biological Activity: Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(2E)-Diethyl fumarate | 98.97% | Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria. | ||||||||||||||||||||
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Diethyl fumarate (Standard) | ≥98% | Diethyl fumarate (Standard) is the analytical standard of Diethyl fumarate (HY-W010056). This product is intended for research and analytical applications. Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin (HY-N0005) hybridize to exert neuroprotective effects. | ||||||||||||||||||||
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References
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[1]. Di Martino RMC, et al. Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease. ACS Chem Neurosci. 2020 Sep 2;11(17):2728-2740.
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[2]. Lahti A, Maibach HI. Contact urticaria from diethyl fumarate. Contact Dermatitis. 1985 Mar;12(3):139-40.
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