623-91-6
623-91-6
Chemical Structure
(2E)-Diethyl fumarate
- CAS No.: 623-91-6
- Formula:C8H12O4
- Molecular Weight:172.18
IUPAC Name: diethyl fumarate
InChIKey: IEPRKVQEAMIZSS-AATRIKPKSA-N
SMILES: O=C(OCC)/C=C/C(OCC)=O
Biological Activity: Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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(2E)-Diethyl fumarate | 98.97% | Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria. | ||||||||||||||||||||
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Diethyl fumarate (Standard) | ≥98% | Diethyl fumarate (Standard) is the analytical standard of Diethyl fumarate (HY-W010056). This product is intended for research and analytical applications. Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and reactant in the Diels-Alder reaction. Diethyl fumarate is a reputed skin irritant. Diethyl fumarate can causes non-immunologic contact urticaria on skin. Diethyl fumarate and Curcumin (HY-N0005) hybridize to exert neuroprotective effects. | ||||||||||||||||||||
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Dimethyl fumarate | 99.95% | Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research. | ||||||||||||||||||||
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Diethyl pentanedioate (Standard) | ≥98% | Diethyl pentanedioate (Standard) is the analytical standard of Diethyl pentanedioate. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Ethyl (E)-2-hexenoate | Ethyl (E)-2-hexenoate consists of a six-carbon chain with a double bond between the 2nd and 3rd carbon atoms, an ethyl ester group attached to the 1st carbon atom, and a A methyl group connected by 4 carbon atoms. This compound has a fruity, sweet or floral aroma and is commonly used as a flavoring in foods such as baked goods, confectionary and beverages. | |||||||||||||||||||||
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Monoethyl fumarate | 99.88% | Monoethyl fumarate is the monoethyl ester form of Fumaric acid (HY-W015883). Monoethyl fumarate is the activator for Nrf2. Monoethyl fumarate is a kind of effective preservative and polymerization agent for macromolecular material. | ||||||||||||||||||||
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Diethyl itaconate,98% (stabilized with TBC)-13C5 | Diethyl itaconate,98% (stabilized with TBC)-13C5 (Itaconic Acid Diethyl Ester (stabilized with TBC)-13C5) is the 13C-labeled Diethyl itaconate,98% (stabilized with TBC) (HY-W143131). | |||||||||||||||||||||
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Ethylene glycol diacrylate | 99.43% | Ethylene glycol diacrylate (Ethylene diacrylate) is a polymer precursor used to form covalently crosslinked hydrogels with a degree of polymerization of 13. | ||||||||||||||||||||
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Diethyl chloromaleate | Diethyl chloromaleate is a biochemical reagent. | |||||||||||||||||||||
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Diethyl succinate | 98.0% | Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings. | ||||||||||||||||||||
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Diethyl succinate-13C4 | Diethyl succinate-13C4 is the 13C labeled Diethyl succinate. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring. | |||||||||||||||||||||
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Diethyl maleate | 98.05% | Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO-. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases. | ||||||||||||||||||||
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References
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[1]. Di Martino RMC, et al. Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson's Disease. ACS Chem Neurosci. 2020 Sep 2;11(17):2728-2740.
[Content Brief] -
[2]. Lahti A, Maibach HI. Contact urticaria from diethyl fumarate. Contact Dermatitis. 1985 Mar;12(3):139-40.
[Content Brief]
