6515-36-2
Chemical Structure
7-Hydroxyflavanone
- CAS No.: 6515-36-2
- Formula:C15H12O3
- Molecular Weight:240.25
IUPAC Name: 7-hydroxy-2-phenylchroman-4-one
InChIKey: SWAJPHCXKPCPQZ-UHFFFAOYSA-N
SMILES: O=C1CC(C2=CC=CC=C2)OC3=C1C=CC(O)=C3
Biological Activity: 7-Hydroxyflavanone is an aromatase (CYP19) activity inhibitor found in plants with an IC50 of 65 μM, and it also possesses 20S proteasome inhibitory activity. 7-Hydroxyflavanone significantly inhibits primary humoral immunity to SRBC in mice and weakly suppresses DTH. 7-Hydroxyflavanone 1 attenuates Doxorubicin (HY-15142A)-induced oxidative stress, IL-6 inflammation, mitochondrial dysfunction, caspase 3/7 activation, apoptosis, and necrosis, and upregulates the PGC-1α/pAMPK/Beclin-1 autophagy-related pathway. 7-Hydroxyflavanone is extensively metabolized by various fungi, undergoing multiple structural modifications. 7-Hydroxyflavanone can be used in research related to Doxorubicin-induced cardiomyopathy and immune system diseases[1][2][3][4].
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7-Hydroxyflavanone | 99.59% | 7-Hydroxyflavanone is an aromatase (CYP19) activity inhibitor found in plants with an IC50 of 65 μM, and it also possesses 20S proteasome inhibitory activity. 7-Hydroxyflavanone significantly inhibits primary humoral immunity to SRBC in mice and weakly suppresses DTH. 7-Hydroxyflavanone 1 attenuates Doxorubicin (HY-15142A)-induced oxidative stress, IL-6 inflammation, mitochondrial dysfunction, caspase 3/7 activation, apoptosis, and necrosis, and upregulates the PGC-1α/pAMPK/Beclin-1 autophagy-related pathway. 7-Hydroxyflavanone is extensively metabolized by various fungi, undergoing multiple structural modifications. 7-Hydroxyflavanone can be used in research related to Doxorubicin-induced cardiomyopathy and immune system diseases. | ||||||||||||||||||||
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References
- [1]. Mikell JR, et al. Bioconversion of 7-hydroxyflavanone: isolation, characterization and bioactivity evaluation of twenty-one phase I and phase II microbial metabolites. Chemical & pharmaceutical bulletin. 2012;60(9):1139-45.
- [2]. Sangweni NF, et al. Doxorubicin-Induced Cardiomyopathy: A Preliminary Study on the Cardioprotective Benefits of 7-Hydroxyflavanone. International journal of molecular sciences. 2023 Oct 20;24(20):15395.
- [3]. Sanderson JT, et al. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicological sciences : an official journal of the Society of Toxicology. 2004 Nov;82(1):70-9. [Content Brief]
- [4]. Sharma ML, et al. Actions of some flavonoids on specific and non-specific immune mechanisms. Phytomedicine. 1996 Sep;3(2):191-5.
