6953-61-3
Chemical Structure
1-Naphthohydroxamic acid
- CAS No.: 6953-61-3
- Formula:C11H9NO2
- Molecular Weight:187.19
IUPAC Name: N-hydroxy-1-naphthamide
InChIKey: JRZGPWOEHDOVMC-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=CC=CC2=CC=C1)NO
Biological Activity: 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1-Naphthohydroxamic acid | 99.59% | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. | ||||||||||||||||||||
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- [1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. [Content Brief]
- [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9. [Content Brief]
Keywords
