95-25-0
95-25-0
Chemical Structure
Chlorzoxazone
- CAS No.: 95-25-0
- Formula:C7H4ClNO2
- Molecular Weight:169.57
IUPAC Name: 5-chlorobenzo[d]oxazol-2(3H)-one
InChIKey: TZFWDZFKRBELIQ-UHFFFAOYSA-N
SMILES: O=C1OC2=CC=C(Cl)C=C2N1
Biological Activity: Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune encephalomyelitis[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chlorzoxazone | 99.77% | Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune encephalomyelitis. | ||||||||||||||||||||
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Chlorzoxazone (Standard) | 99.81% | Chlorzoxazone (Standard) is the analytical standard of Chlorzoxazone. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Chlorzoxazone-13C,15N,d2 | Chlorzoxazone-13C,15N,d2 is 13C-, 15N-, and deuterium-labeled Chlorzoxazone (HY-B1462). | |||||||||||||||||||||
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Chlorzoxazone-13C | Chlorzoxazone-13C is the 13C labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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Chlorzoxazone-d3 | 99.88% | Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. | ||||||||||||||||||||
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2-Mercaptobenzimidazole-d4 | 2-Mercaptobenzimidazole-d4 is the deuterium labeled 2-Benzimidazolethiol. | |||||||||||||||||||||
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Zoxazolamine (Standard) | ≥98% | Zoxazolamine (Standard) is the analytical standard of Zoxazolamine. This product is intended for research and analytical applications. Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. | ||||||||||||||||||||
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Coixol (Standard) | 98.67% | Coixol (Standard) (6-Methoxy-2-benzoxazolinone (Standard)) is the analytical standard of Coixol (HY-N0936). This product is intended for research and analytical applications. Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level. | ||||||||||||||||||||
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Indole-d6 | 95.40% | Indole-d6 is the deuterium labeled Indole. Indole is an endogenous metabolite. | ||||||||||||||||||||
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6-Chloroindole | 6-Chloroindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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5-Methoxy-2-benzimidazolethiol-d3 | 5-Methoxy-2-benzimidazolethiol-d3 is the deuterated-labeled 5-Methoxy-2-benzimidazolethiol (HY-W008378). 5-Methoxy-2-benzimidazolethiol is a benzimidazole derivative. 5-Methoxy-2-benzimidazolethiol can serve as a ligand for transition metal complexes. | |||||||||||||||||||||
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2-Benzoxazolinone (Standard) | 98.56% | 2-Benzoxazolinone (Standard) is the analytical standard of 2-Benzoxazolinone. This product is intended for research and analytical applications. 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent. | ||||||||||||||||||||
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5-Chloro-2-benzothiazolinone | 99.0% | 5-Chloro-2-benzothiazolinone is an antifouling agent. MEIPT-20 grafted with 5-Chloro-2-benzothiazolinone exhibits activity against Escherichia coli, Staphylococcus aureus, Pseudoalteromonas xiamenensis, as well as attached diatoms including the genus Halamphora and Nitzschia closterium. | ||||||||||||||||||||
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6-Hydroxy Chlorzoxazone-d2 | 6-Hydroxy Chlorzoxazone-d2 is deuterium labeled 6-Hydroxy Chlorzoxazone. 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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6-Hydroxy Chlorzoxazone-15N,d2 | 96.54% | 6-Hydroxy Chlorzoxazone-15N,d2 is the 15N and deuterium labeled 6-Hydroxy Chlorzoxazone (HY-W016221). 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | ||||||||||||||||||||
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Tyrosinase-IN-22 | 98.77% | Tyrosinase-IN-22 (compound 4) is an inhibitor of tyrosinase substrates (L-tyrosine and L-dopa) with IC50s of 60 nM and 30 nM, respectively. Tyrosinase-IN-22 also shows potent antioxidant and anti-melanogenic properties, thus can be used for relevant researches. | ||||||||||||||||||||
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CBIO | CBIO (Compound 4e) is a 1,2-Benzisoxazole (HY-W103317) derivative. | |||||||||||||||||||||
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6-Chloro-2-benzoxazolinone | 99.12% | 6-Chloro-2-benzoxazolinone (6-Chlorobenzo[d]oxazol-2 (3H)-one) is a derivative of DIMBOA (HY-N7432) and an antibacterial agent. The minimum inhibitory concentration (MIC) of 6-Chloro-2-benzoxazolinone against Ralstonia solanacearum is 100 mg/L, and its minimum bactericidal concentration (MBC) is 500 mg/L. 6-Chloro-2-benzoxazolinone reduces biofilm formation and inhibits swarming motility of *Ralstonia solanacearum*. It can be used for the research of bacterial wilt. | ||||||||||||||||||||
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Indole-d4 | Indole-d4 is the deuterium labeled Indole (HY-W001132). Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule. | |||||||||||||||||||||
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1H-Indole-d5 | 1H-Indole-2,4,5,6,7-d5 is deuterated labeled 1H-Indole-2,4,5,6,7. | |||||||||||||||||||||
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6-Hydroxy Chlorzoxazone-13C6 | 6-Hydroxy Chlorzoxazone-13C6 is a the 13C-labeled 6-Hydroxy Chlorzoxazone (HY-W016221). 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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1H-Benzotriazole-4,5,6,7-d4 | 99.9% | 1H-Benzotriazole-4,5,6,7-d4 is the deuterium labeled 1H-Benzo[d][1,2,3]triazole. | ||||||||||||||||||||
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References
- [1]. Yamamura Y, et al. Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica. 2015 Apr;45(4):353-360. [Content Brief]
- [2]. Lu T, et al. Action of chlorzoxazone on Ca2+movement and viability in human oral cancer cells. Chin J Physiol. 2019 May-Jun;62(3):123-130. [Content Brief]
- [3]. Deng L, et al. Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation. Cell Death Dis. 2020 Mar 2;11(3):158. [Content Brief]
- [4]. Lv J, et al. Chlorzoxazone Alleviates Experimental Autoimmune Encephalomyelitis via Inhibiting IL-6 Secretion of Dendritic Cells. J Immunol. 2022 Apr 1;208(7):1545-1553. [Content Brief]
- [5]. Liu YC, et al. Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells. Brain Res. 2003 Jan 3;959(1):86-97. [Content Brief]
- [6]. Bai Y, et al. Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo. Int Immunopharmacol. 2020 Nov;88:106790. [Content Brief]
- [7]. Dong DL, et al. Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6. [Content Brief]
- [8]. Gao L, et al. Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1123-9. [Content Brief]
- [9]. Baek HW, et al. Pharmacokinetics of chlorzoxazone in rats with diabetes: Induction of CYP2E1 on 6-hydroxychlorzoxazone formation. J Pharm Sci. 2006 Nov;95(11):2452-62. [Content Brief]
- [10]. Hopf FW, et al. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry. 2011 Apr 1;69(7):618-24. [Content Brief]
