Chlorzoxazone-d3
Based on 1 Customer Validation
Chlorzoxazone-d3 is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 1185173-60-7
- Formula: C7HD3ClNO2
- Molecular Weight:172.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185173-60-7
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Unlabeled Cas 95-25-0
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Appearance Solid
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Molecular Weight 172.58
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Formula C7HD3ClNO2
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Color Light yellow to light brown
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SMILES
O=C1OC2=C([2H])C([2H])=C(Cl)C([2H])=C2N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (579.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Yamamura Y, et al. Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica. 2015 Apr;45(4):353-360. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7944 mL | 28.9721 mL | 57.9441 mL | 144.8604 mL |
| 5 mM | 1.1589 mL | 5.7944 mL | 11.5888 mL | 28.9721 mL | |
| 10 mM | 0.5794 mL | 2.8972 mL | 5.7944 mL | 14.4860 mL | |
| 15 mM | 0.3863 mL | 1.9315 mL | 3.8629 mL | 9.6574 mL | |
| 20 mM | 0.2897 mL | 1.4486 mL | 2.8972 mL | 7.2430 mL | |
| 25 mM | 0.2318 mL | 1.1589 mL | 2.3178 mL | 5.7944 mL | |
| 30 mM | 0.1931 mL | 0.9657 mL | 1.9315 mL | 4.8287 mL | |
| 40 mM | 0.1449 mL | 0.7243 mL | 1.4486 mL | 3.6215 mL | |
| 50 mM | 0.1159 mL | 0.5794 mL | 1.1589 mL | 2.8972 mL | |
| 60 mM | 0.0966 mL | 0.4829 mL | 0.9657 mL | 2.4143 mL | |
| 80 mM | 0.0724 mL | 0.3622 mL | 0.7243 mL | 1.8108 mL | |
| 100 mM | 0.0579 mL | 0.2897 mL | 0.5794 mL | 1.4486 mL |
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