CB2R agonist 4
CB2R agonist 4 is a cannabinoid receptor 2 (CB2R) agonist with an EC50 value of 6.9 μM. CB2R agonist 4 can induce cell apoptosis, ROS production and protein misfolding. CB2R agonist 4 shows cytotoxicity to a panel of tumor cell lines. CB2R agonist 4 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 182496-82-8
- Formula: C21H22N2O4
- Molecular Weight:366.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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CB2R 6.9 μM (EC50) |
CB2R agonist 4 (Compound 63) shows cytotoxicity to HaCaT, HEPG2, A375, SHSY5Y, MCF7, and A549 cells, with EC50 values of 21.41, 2.17, 2.29, 23.21, 27.93 and 36.4μM, respectively[1].
CB2R agonist 4 has remarkable inhibition of TRPM8 (IC50 = 0.36 μM) and BRD4 (IC50 = 0.11 μM), associated with activation of TRPA1 (EC50 = 2.54 μM), and a weakinhibition of BRK (IC50 = 29.17 μM)[1].
CB2R agonist 4 induces lipid remodeling with diacylglycerols, cholesterol esters reduction and lysophosphatidylcholines, lysophosphatidylethanolamines increase in A357 cells[1].
CB2R agonist 4 (2.5-10 μM, 2-8 h) induces ROS production in A357 cells[1].
CB2R agonist 4 (5-20 μM, 24 h) increases misfolded protein levels in A357 cells[1].
CB2R agonist 4 (1.25-5 μM, 72 h) induces apoptosis in A357 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A357 cells
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Concentration:5, 10 and 20 μM
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Incubation Time:24 h
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Result:Showed the greatest increase in fluorescence at 20 μM.
Chemical Information
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CAS No. 182496-82-8
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Molecular Weight 366.41
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Formula C21H22N2O4
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SMILES
O=C(OCC1=CC=CC=C1)[C@@H](N2C(C3=CC=CC=C3NC2=O)=O)CC(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB2R agonist 4 Related Classifications
HY-175481 Related Classifications
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